Inhibitors | Comment | Organism | Structure |
---|---|---|---|
fosmidomycin | - |
Escherichia coli | |
FR900098 | fosmidomycin homologue | Escherichia coli | |
additional information | neither the sulfone (N-hydroxy-N-[3-(alkylsulfonyl)propyl]acetamides) nor the sulfonamide derivatives (N-hydroxy-N-(3-sulfamoylpropyl) acetamide and N-hydroxy-N-(3-(N-alkylsulfamoyl)propyl)acetamide) of FR900098 display any significant inhibitory activity against DXR at a concentration of 0.03 mM. Importance of the negative charge for the binding of fosmidomycin-like inhibitors to DXR. Uncharged molecules are virtually inactive whereas derivatives that possess only one instead of two negative charges are markedly less active. It is possible to regain some of the activity that is lost by the reduction of the charge by occupation of hitherto unexploited areas of the enzyme | Escherichia coli | |
[3-(acetyl(hydroxy)amino)propyl]phosphonic acid 3-methylbutyl ester | - |
Escherichia coli | |
[3-(acetyl(hydroxy)amino)propyl]phosphonic acid mono(2-naphthalen-1-yl-ethyl) ester | - |
Escherichia coli | |
[3-(acetyl(hydroxy)amino)propyl]phosphonic acid mono(2-naphthalen-2-yl-ethyl) ester | - |
Escherichia coli | |
[3-(acetyl(hydroxy)amino)propyl]phosphonic acid mono-n-butyl ester | - |
Escherichia coli | |
[3-(acetyl(hydroxy)amino)propyl]phosphonic acid mono-n-propyl ester | - |
Escherichia coli | |
[3-(acetyl(hydroxy)amino)propyl]phosphonic acid monomethyl ester | - |
Escherichia coli | |
[3-(acetyl(hydroxy)amino)propyl]phosphonic acid monophenethyl ester | - |
Escherichia coli | |
[3-(acetyl(hydroxy)amino)propyl]phosphonic monoethyl ester | - |
Escherichia coli |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Escherichia coli | |
Mn2+ | - |
Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P45568 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-deoxy-D-xylulose 5-phosphate + NADPH + H+ | - |
Escherichia coli | 2-C-methyl-D-erythritol 4-phosphate + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
deoxyxylulosephosphate reductoisomerase | - |
Escherichia coli |
DOXP reductoisomerase | - |
Escherichia coli |
DXR | - |
Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Escherichia coli |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000035 | - |
at 0.03 mM | Escherichia coli | fosmidomycin | |
0.000035 | - |
at 0.03 mM | Escherichia coli | FR900098 | |
0.00049 | - |
at 0.03 mM | Escherichia coli | [3-(acetyl(hydroxy)amino)propyl]phosphonic acid monophenethyl ester | |
0.0016 | - |
at 0.03 mM | Escherichia coli | [3-(acetyl(hydroxy)amino)propyl]phosphonic acid mono(2-naphthalen-2-yl-ethyl) ester | |
0.0021 | - |
at 0.03 mM | Escherichia coli | [3-(acetyl(hydroxy)amino)propyl]phosphonic acid 3-methylbutyl ester | |
0.0024 | - |
at 0.03 mM | Escherichia coli | [3-(acetyl(hydroxy)amino)propyl]phosphonic acid mono(2-naphthalen-1-yl-ethyl) ester | |
0.0039 | - |
at 0.03 mM | Escherichia coli | [3-(acetyl(hydroxy)amino)propyl]phosphonic acid mono-n-butyl ester | |
0.016 | - |
at 0.03 mM | Escherichia coli | [3-(acetyl(hydroxy)amino)propyl]phosphonic acid mono-n-propyl ester | |
0.023 | - |
at 0.03 mM | Escherichia coli | [3-(acetyl(hydroxy)amino)propyl]phosphonic monoethyl ester | |
0.05 | - |
at 0.03 mM | Escherichia coli | [3-(acetyl(hydroxy)amino)propyl]phosphonic acid monomethyl ester |