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Literature summary for 1.1.1.27 extracted from

  • Vivas, L.; Easton, A.; Kendrick, H.; Cameron, A.; Lavandera, J.L.; Barros, D.; de las Heras, F.G.; Brady, R.L.; Croft, S.L.
    Plasmodium falciparum: stage specific effects of a selective inhibitor of lactate dehydrogenase (2005), Exp. Parasitol., 111, 105-114.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
4-hydroxy-1,2,5-oxadiazole-3-carboxylic acid trophozoites are the most susceptible stages to exposure to 4-hydroxy-1,2,5-oxadiazole-3-carboxylic acid Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
ring stage
-
 Plasmodium falciparum
-
trophozoite
-
 Plasmodium falciparum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-lactate + 3-acetyl pyridine adenine dinucleotide assay is based on reduction of 3-acetyl pyridine adenine dinucleotide that is specific for PfLDH, which allows the distinction of PfLDH from that of the host erythrocyte Plasmodium falciparum pyruvate + reduced 3-acetyl pyridine adenine dinucleotide
-
 ?

Synonyms

Synonyms Comment Organism
PfLDH
-
 Plasmodium falciparum

Cofactor

Cofactor Comment Organism Structure
3-acetylpyridine adenine dinucleotide assay is based on reduction of 3-acetyl pyridine adenine dinucleotide that is specific for PfLDH, which allows the distinction of PfLDH from that of the host erythrocyte Plasmodium falciparum