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Literature summary for 1.1.1.27 extracted from

  • Zhadin, N.; Gulotta, M.; Callender, R.
    Probing the role of dynamics in hydride transfer catalyzed by lactate dehydrogenase (2008), Biophys. J., 95, 1974-1984.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.15
-
pyruvate
-
Sus scrofa
3.3
-
Lactate
-
Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-lactate + NAD+ an encounter complex is formed between LDH-NAD+ and lactate, collapses to form a chemically active species and loop closure/opening steps Sus scrofa pyruvate + NADH + H+
-
?
pyruvate + NADH + H+ an encounter complex is formed between LDH-NADH and pyruvate, collapses to form a chemically active species and loop closure/opening steps Sus scrofa L-lactate + NAD+
-
?
pyruvate + NADH + H+
-
Sus scrofa lactate + NAD+
-
?

Synonyms

Synonyms Comment Organism
lactate dehydrogenase
-
Sus scrofa
LDH
-
Sus scrofa

Cofactor

Cofactor Comment Organism Structure
NADH
-
Sus scrofa