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Literature summary for 1.1.1.27 extracted from

  • Echigoya, Y.; Sato, T.; Itou, T.; Endo, H.; Sakai, T.
    Molecular characterization and expression pattern of the equine lactate dehydrogenase A and B genes (2009), Gene, 447, 40-50.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
LDHA, DNA and amino acid sequence determination and analysis, genetic structure, and sequence comparisons, phylogenetic analysis, overview Equus caballus
LDHB, DNA and amino acid sequence determination and analysis, genetic structure, and sequence comparisons, phylogenetic analysis, overview Equus caballus

Protein Variants

Protein Variants Comment Organism
H88X/H226X substitution of His 88 and 226 of the eLDHA monomer alters the surface charge of equine LDH tetramer, the residues are located in an important region affecting the catalytic kinetics Equus caballus
additional information deletion of Glu 14 of the eLDHB monomer alters the surface charge of equine LDH tetramers and the residue is located in an important region affecting the catalytic kinetics Equus caballus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-lactate + NAD+ Equus caballus
-
pyruvate + NADH + H+
-
r

Organism

Organism UniProt Comment Textmining
Equus caballus B7XH73 eLDHA; isozymes LDH A, encoded by gene LDHA
-
Equus caballus C6L1K8 eLDHB, fragment; isozymes LDH B, encoded by gene LDHB
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Equus caballus
-
heart
-
Equus caballus
-
uterine cervix muscle Equus caballus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-lactate + NAD+
-
Equus caballus pyruvate + NADH + H+
-
r

Subunits

Subunits Comment Organism
More three-dimensional structure models of eLDHA monomeric and tetrameric proteins are constructed by homology modeling, structure analysis and comparison to the human enzymes, PDB accession number 1i10, overview Equus caballus
More three-dimensional structure models of eLDHB monomeric and tetrameric proteins are constructed by homology modeling, structure analysis and comparison to the human enzymes, PDB accession number 1i0z, overview Equus caballus

Synonyms

Synonyms Comment Organism
eLDHA
-
Equus caballus
eLDHB
-
Equus caballus
lactate dehydrogenase A
-
Equus caballus
lactate dehydrogenase B
-
Equus caballus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Equus caballus
NADH
-
Equus caballus