Cloned (Comment) | Organism |
---|---|
LDHA, DNA and amino acid sequence determination and analysis, genetic structure, and sequence comparisons, phylogenetic analysis, overview | Equus caballus |
LDHB, DNA and amino acid sequence determination and analysis, genetic structure, and sequence comparisons, phylogenetic analysis, overview | Equus caballus |
Protein Variants | Comment | Organism |
---|---|---|
H88X/H226X | substitution of His 88 and 226 of the eLDHA monomer alters the surface charge of equine LDH tetramer, the residues are located in an important region affecting the catalytic kinetics | Equus caballus |
additional information | deletion of Glu 14 of the eLDHB monomer alters the surface charge of equine LDH tetramers and the residue is located in an important region affecting the catalytic kinetics | Equus caballus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-lactate + NAD+ | Equus caballus | - |
pyruvate + NADH + H+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Equus caballus | B7XH73 | eLDHA; isozymes LDH A, encoded by gene LDHA | - |
Equus caballus | C6L1K8 | eLDHB, fragment; isozymes LDH B, encoded by gene LDHB | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Equus caballus | - |
heart | - |
Equus caballus | - |
uterine cervix | muscle | Equus caballus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-lactate + NAD+ | - |
Equus caballus | pyruvate + NADH + H+ | - |
r |
Subunits | Comment | Organism |
---|---|---|
More | three-dimensional structure models of eLDHA monomeric and tetrameric proteins are constructed by homology modeling, structure analysis and comparison to the human enzymes, PDB accession number 1i10, overview | Equus caballus |
More | three-dimensional structure models of eLDHB monomeric and tetrameric proteins are constructed by homology modeling, structure analysis and comparison to the human enzymes, PDB accession number 1i0z, overview | Equus caballus |
Synonyms | Comment | Organism |
---|---|---|
eLDHA | - |
Equus caballus |
eLDHB | - |
Equus caballus |
lactate dehydrogenase A | - |
Equus caballus |
lactate dehydrogenase B | - |
Equus caballus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Equus caballus | |
NADH | - |
Equus caballus |