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Literature summary for 1.1.1.27 extracted from

  • Baker, J.L.; Derr, A.M.; Faustoferri, R.C.; Quivey, R.G.
    Loss of NADH oxidase activity in Streptococcus mutans leads to Rex-mediated overcompensation in NAD+ regeneration by lactate dehydrogenase (2015), J. Bacteriol., 197, 3645-3657.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene ldh, real-time quantitative reverse transcription-PCR enzyme expression analysis Streptococcus mutans serotype c

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-lactate + NAD+ Streptococcus mutans serotype c
-
 pyruvate + NADH + H+
-
 r
(S)-lactate + NAD+ Streptococcus mutans serotype c UA159
-
 pyruvate + NADH + H+
-
 r
pyruvate + NADH + H+ Streptococcus mutans serotype c
-
 (S)-lactate + NAD+
-
 r
pyruvate + NADH + H+ Streptococcus mutans serotype c UA159
-
 (S)-lactate + NAD+
-
 r

Organism

Organism UniProt Comment Textmining
Streptococcus mutans serotype c P26283
-
-
Streptococcus mutans serotype c UA159 P26283
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cell culture steady-state growth at pH 7 and pH 5 Streptococcus mutans serotype c
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-lactate + NAD+
-
 Streptococcus mutans serotype c pyruvate + NADH + H+
-
 r
(S)-lactate + NAD+
-
 Streptococcus mutans serotype c UA159 pyruvate + NADH + H+
-
 r
pyruvate + NADH + H+
-
 Streptococcus mutans serotype c (S)-lactate + NAD+
-
 r
pyruvate + NADH + H+
-
 Streptococcus mutans serotype c UA159 (S)-lactate + NAD+
-
 r

Synonyms

Synonyms Comment Organism
L-LDH
-
 Streptococcus mutans serotype c
lactate dehydrogenase
-
 Streptococcus mutans serotype c
LDH
-
 Streptococcus mutans serotype c
SMU.1115
-
 Streptococcus mutans serotype c
SMU_1115
-
 Streptococcus mutans serotype c

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Streptococcus mutans serotype c
NADH
-
 Streptococcus mutans serotype c

Expression

Organism Comment Expression
Streptococcus mutans serotype c deletion of water-forming NADH oxidase NOX in Streptococcus mutans leads to significantly elevated lactate dehydrogenase activity and gene ldh transcription in the DELTAnox strain, which is mediated in part by the redox-sensing regulator Rex. Rex activation of ldh transcription up

General Information

General Information Comment Organism
malfunction loss of water-forming NADH oxidase NOX activity in Streptococcus mutans leads to Rex-mediated overcompensation in NAD+ regeneration by lactate dehydrogenase. The altered transcriptome and metabolome of the DELTAnox strain are sufficient to impair its ability to compete with commensal peroxigenic oral streptococci during growth under aerobic conditions, phenotype, overview Streptococcus mutans serotype c