Literature summary for 1.1.1.27 extracted from

Lee, J.; In, J.; Park, J.; Shin, J.; Park, J.; Sung, B.; Sohn, J.; Seo, J.; Park, J.; Kim, S.; Kweon, D.
Co-expression of two heterologous lactate dehydrogenases genes in Kluyveromyces marxianus for L-lactic acid production (2017), J. Biotechnol., 241, 81-86 .

Search for more literature for 1.1.1.27

Application

Application	Comment	Organism
synthesis	engineering of Kluyveromyces marxianus to express and coexpress various heterologous LDH enzymes for L-lactic acid production. LDH enzymes originating from Staphylococcus epidermidis (SeLDH, optimal at pH 5.6), Lactobacillus acidophilus (LaLDH, optimal at pH 5.3), and Bos taurus (BtLDH, optimal at pH 9.8) are functionally expressed individually and in combination. A strain co-expressing SeLDH and LaLDH produces 16.0 g/l L-lactic acid, whereas the strains expressing those enzymes individually produces only 8.4 and 6.8 g/l, respectively. This coexpressing strain produces 24.0 g/l L-lactic acid with a yield of 0.48 g/g glucose in the presence of CaCO3	Lactobacillus acidophilus
synthesis	engineering of Kluyveromyces marxianus to express and coexpress various heterologous LDH enzymes for L-lactic acid production. LDH enzymes originating from Staphylococcus epidermidis (SeLDH, optimal at pH 5.6), Lactobacillus acidophilus (LaLDH, optimal at pH 5.3), and Bos taurus (BtLDH, optimal at pH 9.8) are functionally expressed individually and in combination. A strain coexpressing SeLDH and LaLDH produces 16.0 g/l L-lactic acid, whereas the strains expressing those enzymes individually produces only 8.4 and 6.8 g/l, respectively. This coexpressing strain produces 24.0 g/l L-lactic acid with a yield of 0.48 g/g glucose in the presence of CaCO3	Staphylococcus epidermidis

Organism

Organism	UniProt	Comment	Textmining
Lactobacillus acidophilus	Q5FMB0	-	-
Lactobacillus acidophilus ATCC 700396	Q5FMB0	-	-
Staphylococcus epidermidis	Q8CMZ0	-	-
Staphylococcus epidermidis ATCC 12228	Q8CMZ0	-	-

Synonyms

Synonyms	Comment	Organism
LDH1	-	Lactobacillus acidophilus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)