Literature summary for 1.1.1.270 extracted from

Chang, Y.C.; Lin, C.H.; Lin, J.C.; Cheng, S.P.; Chen, S.N.; Liu, C.L.
Inhibition of 3beta-hydroxysteroid dehydrogenase type 1 suppresses interleukin-6 in breast cancer (2019), J. Surg. Res., 241, 8-14 .

Search for more literature for 1.1.1.270

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P14060	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast cancer cell	expression of 3beta-hydroxysteroid dehydrogenase type 1 (HSD3B1) in breast cancer is associated with shorter recurrence-free survival, and genetic or pharmacologic inhibition of HSD3B1 reduced colony formation and xenograft growth	Homo sapiens	-
MDA-MB-231 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
3beta-hydroxysteroid dehydrogenase type 1	-	Homo sapiens
HSD3B1	-	Homo sapiens

General Information

General Information	Comment	Organism
drug target	inhibition of 3beta-hydroxysteroid dehydrogenase type 1 suppresses interleukin-6 in breast cancer. The therapeutic potential of targeting HSD3B1 is in part mediated by IL-6 suppression	Homo sapiens
malfunction	interleukin-6 treatment partially reduces the cytotoxicity augmented by the HSD3B1 knockdown	Homo sapiens
metabolism	expression of 3beta-hydroxysteroid dehydrogenase type 1 (HSD3B1) in breast cancer is associated with shorter recurrence-free survival, and genetic or pharmacologic inhibition of HSD3B1 reduced colony formation and xenograft growth	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)