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Literature summary for 1.1.1.271 extracted from

  • Kizuka, Y.; Nakano, M.; Yamaguchi, Y.; Nakajima, K.; Oka, R.; Sato, K.; Ren, C.T.; Hsu, T.L.; Wong, C.H.; Taniguchi, N.
    An alkynyl-fucose halts hepatoma cell migration and invasion by inhibiting GDP-fucose-synthesizing enzyme FX, TSTA3 (2017), Cell Chem. Biol., 24, 1467-1478 .
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
6-alkynyl-fucose competitive inhibitor, potently and selectively inhibits the enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GDP-4-dehydro-alpha-D-rhamnose + NADPH + H+ Homo sapiens
-
 GDP-beta-L-fucose + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13630
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatoma cell the enzyme is aberrantly upregulated in human hepatoma Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GDP-4-dehydro-alpha-D-rhamnose + NADPH + H+
-
 Homo sapiens GDP-beta-L-fucose + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
GDP-4-keto-6-deoxymannose 3,5-epimerase-4-reductase
-
 Homo sapiens
GDP-Fuc synthase
-
 Homo sapiens
GDP-fucose-synthesizing enzyme FX
-
 Homo sapiens
TSTA3
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is aberrantly upregulated in human hepatoma up

General Information

General Information Comment Organism
drug target 6-alkynyl-fucose effectively suppresses invasion of hepatoma cells, particularly for Fuc-high hepatoma, suggesting that this fucose analog can be used to suppress cancer metastasis by blocking aberrant fucosylation in cancer cells Homo sapiens