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Literature summary for 1.1.1.283 extracted from

  • Greig, N.; Wyllie, S.; Patterson, S.; Fairlamb, A.H.
    A comparative study of methylglyoxal metabolism in trypanosomatids (2009), FEBS J., 276, 376-386.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Leishmania major
-
-
-
Leishmania major Friedlin
-
-
-
Trypanosoma brucei
-
-
-
Trypanosoma cruzi
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0048
-
at 25°C, in 50 mM HEPES (pH 7.0) Trypanosoma cruzi
0.0053
-
at 25°C, in 50 mM HEPES (pH 7.0) Leishmania major
0.0094
-
at 25°C, in 50 mM HEPES (pH 7.0) Trypanosoma brucei

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methylglyoxal + NADPH + H+
-
Trypanosoma brucei L-lactaldehyde + NADP+
-
?
methylglyoxal + NADPH + H+
-
Trypanosoma cruzi L-lactaldehyde + NADP+
-
?
methylglyoxal + NADPH + H+
-
Leishmania major L-lactaldehyde + NADP+
-
?
methylglyoxal + NADPH + H+
-
Leishmania major Friedlin L-lactaldehyde + NADP+
-
?

Synonyms

Synonyms Comment Organism
MeGR
-
Trypanosoma brucei
MeGR
-
Trypanosoma cruzi
MeGR
-
Leishmania major
NADPH-dependent methylglyoxal reductase
-
Trypanosoma brucei
NADPH-dependent methylglyoxal reductase
-
Trypanosoma cruzi
NADPH-dependent methylglyoxal reductase
-
Leishmania major