Crystallization (Comment) | Organism |
---|---|
sitting-drop vapor diffusion at 4°C. A 15-20 mg/ml enzyme solution equilibrated with a mother liquor containing 0.1 M phosphate buffer, pH 7.1, 10 mM ZnSO4, 1 mM DTT, and 12-16% PEG 8000. Ternary complex with S-(hydroxymethyl)glutathione and the reduced coenzyme to 2.6 A resolution | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zinc | in the ternary complex with S-(hydroxymethyl)glutathione and the reduced coenzyme the active site zinc has a tetrahedral coordination environment with Cys44, His66 and Cys173 as the protein ligands in addition to S-(hydroxymethy)glutathione | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme plays an important role in the metabolism of glutathione adducts such as S-(hydroxymethyl)glutathione and S-nitrosoglutathione | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme plays an important role in the metabolism of glutathione adducts such as S-(hydroxymethyl)glutathione and S-nitrosoglutathione | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Glutathione-dependent formaldehyde dehydrogenase | - |
Homo sapiens |