Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bronchoalveolar lavage | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-nitrosoglutathione + NADH + H+ | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GSNOR | - |
Homo sapiens |
S-nitrosoglutathione reductase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | S-nitrosothiol content is decreased in asthmatic bronchoalveolar lavage compared with control bronchoalveolar lavage and correlates inversely with GSNOR expression in bronchoalveolar lavage cell lysates. GSNOR activity in bronchoalveolar lavage samples is significantly increased by 2fold in subjects with asthma compared with control subjects and correlates inversely with the provocative concentration of methacholine causing a 20% decrease in FEV(1) | up |
General Information | Comment | Organism |
---|---|---|
physiological function | GSNOR is an important regulator of airway S-nitrosothiol content and airways hyperresponsiveness in human asthma | Homo sapiens |