Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-[1-(4-acetylphenyl)-5-phenyl-1H-pyrrol-2-yl]propanoic acid | exhibits noncompetitive or uncompetitive inhibition against varied concentrations of S-nitrosoglutathione or NADH | Homo sapiens | |
3-[1-(4-acetylphenyl)-5-phenyl-1H-pyrrol-2-yl]propanoic acid | 3-[1-(4-acetylphenyl)-5-phenyl-1H-pyrrol-2-yl]propanoic acid and 4-([2-[(2-cyanobenzyl)sulfanyl]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl)benzoic acid are more effective than 5-chloro-3-[2-[(4-ethoxyphenyl)(ethyl)amino]-2-oxoethyl]-1H-indole-2-carboxylic acid in inhibiting GSNOR inside the cells, dependence of S-nitrosothiols accumulation on the concentration of compound | Mus musculus | |
4-([2-[(2-cyanobenzyl)sulfanyl]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl)benzoic acid | exhibits noncompetitive or uncompetitive inhibition against varied concentrations of S-nitrosoglutathione or NADH | Homo sapiens | |
4-([2-[(2-cyanobenzyl)sulfanyl]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl)benzoic acid | 3-[1-(4-acetylphenyl)-5-phenyl-1H-pyrrol-2-yl]propanoic acid and 4-([2-[(2-cyanobenzyl)sulfanyl]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl)benzoic acid are more effective than 5-chloro-3-[2-[(4-ethoxyphenyl)(ethyl)amino]-2-oxoethyl]-1H-indole-2-carboxylic acid in inhibiting GSNOR inside the cells, dependence of S-nitrosothiols accumulation on the concentration of compound. 4-([2-[(2-cyanobenzyl)sulfanyl]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl)benzoic acid increases the nitrosylation of cellular proteins in RAW264.7 cells in a time-dependent manner | Mus musculus | |
5-chloro-3-[2-[(4-ethoxyphenyl)(ethyl)amino]-2-oxoethyl]-1H-indole-2-carboxylic acid | exhibits noncompetitive or uncompetitive inhibition against varied concentrations of S-nitrosoglutathione or NADH | Homo sapiens | |
5-chloro-3-[2-[(4-ethoxyphenyl)(ethyl)amino]-2-oxoethyl]-1H-indole-2-carboxylic acid | 3-[1-(4-acetylphenyl)-5-phenyl-1H-pyrrol-2-yl]propanoic acid and 4-([2-[(2-cyanobenzyl)sulfanyl]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl)benzoic acid are more effective than 5-chloro-3-[2-[(4-ethoxyphenyl)(ethyl)amino]-2-oxoethyl]-1H-indole-2-carboxylic acid in inhibiting GSNOR inside the cells, dependence of S-nitrosothiols accumulation on the concentration of compound | Mus musculus | |
dodecanoic acid | noncompetitive inhibition | Homo sapiens | |
additional information | GSNOR inhibitors may be novel tools for regulating nitric oxide bioactivity and assessing the role of S-nitrosothiols in vivo | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
RAW-264.7 cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-nitrosoglutathione + NADH + H+ | - |
Mus musculus | ? | - |
? | |
S-nitrosoglutathione + NADH + H+ | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GSNOR | - |
Mus musculus |
GSNOR | - |
Homo sapiens |
S-nitrosoglutathione reductase | - |
Mus musculus |
S-nitrosoglutathione reductase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Mus musculus | |
NADH | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | GSNOR limits nitric oxide-mediated suppression of NF-kappaB and activation of soluble guanylyl cyclase | Mus musculus |