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Literature summary for 1.1.1.284 extracted from

  • Gomes, S.A.; Rangel, E.B.; Premer, C.; Dulce, R.A.; Cao, Y.; Florea, V.; Balkan, W.; Rodrigues, C.O.; Schally, A.V.; Hare, J.M.
    S-nitrosoglutathione reductase (GSNOR) enhances vasculogenesis by mesenchymal stem cells (2013), Proc. Natl. Acad. Sci. USA, 110, 2834-2839.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.284

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
endothelial progenitor cell
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 Mus musculus
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mesenchymal stem cell
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 Mus musculus
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Synonyms

Synonyms Comment Organism
GSNOR
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 Mus musculus
S-nitrosoglutathione reductase
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 Mus musculus

General Information

General Information Comment Organism
malfunction mesenchymal stem cells deficient in GSNOR exhibit markedly diminished capacity for vasculogenesis in an in vitro Matrigel tube–forming assay and in vivo relative to wild-type cells. This decrease is associated with downregulation of the PDGF receptor alpha in GSNOR-/- mesenchymal stem cells, a receptor essential for VEGF-A action in the cells. GSNOR-/- mesenchymal stem cells have a deficient capacity for endothelial differentiation due to downregulation of PDGFRalpha related to NO/GSNOR imbalance, overview Mus musculus
physiological function S-nitrosoglutathione reductase is a denitrosylase that regulates S-nitrosylation Mus musculus