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Literature summary for 1.1.1.300 extracted from

  • Obrochta, K.M.; Krois, C.R.; Campos, B.; Napoli, J.L.
    Insulin regulates retinol dehydrogenase expression and all-trans-retinoic acid biosynthesis through FoxO1 (2015), J. Biol. Chem., 290, 7259-7268.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus Q8VCH7
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-

Synonyms

Synonyms Comment Organism
RDH10
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Mus musculus

Expression

Organism Comment Expression
Mus musculus oral gavage with glucose or injection with insulin decreases Rdh10 mRNA 50% or greater in mouse liver down

General Information

General Information Comment Organism
physiological function energy status regulates all-trans-retinoic acid biosynthesis at the rate-limiting step, catalyzed by retinol dehydrogenases. Six h after re-feeding, isoform Rdh10 expression is decreased 45–63% in liver, pancreas, and kidney, relative to mice fasted 16 h. All-trans-retinoic acid in the liver is decreased 44% 3 h after reduced Rdh expression. Oral gavage with glucose or injection with insulin decreases Rdh10 mRNA 50% or greater in mouse liver Mus musculus