Cloned (Comment) | Organism |
---|---|
gene rdh11, co-expression of GFP-tagged or EYFP-tagged RDH11 with HA-tagged selenoprotein F in HEK-293T cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
selenoprotein F | SELENOF, cloned from a human fetal brain cDNA library, interacts with RDH11 and blocks its enzyme activity to reduce all-trans-retinaldehyde. The reductase activity of RDH11 affected by selenoprotein F | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | co-localization of RDH11 and selenoprotein F | Homo sapiens | 5783 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
all-trans-retinal + NADPH + H+ | Homo sapiens | - |
all-trans-retinol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8TC12 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
eye | RDH11 is involved in the retinal pigment epithelium (RPE) during the retinoid visual cycle | Homo sapiens | - |
prostate gland | - |
Homo sapiens | - |
retinal pigment epithelium | - |
Homo sapiens | - |
testis | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
all-trans-retinal + NADPH + H+ | - |
Homo sapiens | all-trans-retinol + NADP+ | - |
? | |
additional information | RDH11 is able to reduce both all-trans- and cis-retinaldehydes into all-trans- and -cis-retinol (Vitamin A) | Homo sapiens | ? | - |
- |
Synonyms | Comment | Organism |
---|---|---|
RDH11 | - |
Homo sapiens |
retinol dehydrogenase 11 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
evolution | human retinol dehydrogenase 11 RDH11 belongs to the short-chain dehydrogenases/ reductases (SDR) family | Homo sapiens |
metabolism | interaction of selenoprotein F (SELENOF) with retinol dehydrogenase 11 (RDH11) implying a role of selenoprotein F in vitamin A metabolism. Selenoprotein F has been reported to play important roles in oxidative stress, endoplasmic reticulum (ER) stress, and carcinogenesis. Both of selenoprotein F and RDH11 might reduce all-trans-retinaldehyde into all-trans-retinol, but overexpressed selenoprotein F and RDH11 inhibit the enzyme activity of each other | Homo sapiens |
physiological function | RDH11 is an enzyme for the reduction of all-trans-retinaldehyde to all-trans-retinol (vitamin A). It is involved in the retinal pigment epithelium (RPE) during the retinoid visual cycle. Interaction of selenoprotein F (SELENOF) with retinol dehydrogenase 11 (RDH11) is analyzed by yeast two-hybrid system and determination of production of retinol. The production of retinol is decreased by SELENOF overexpression, resulting in more retinaldehyde | Homo sapiens |