Literature summary for 1.1.1.300 extracted from

Guan, F.; Wang, L.; Hao, S.; Wu, Z.; Bai, J.; Kang, Z.; Zhou, Q.; Chang, H.; Yin, H.; Li, D.; Tian, K.; Ma, J.; Zhang, G.; Zhang, J.
Retinol dehydrogenase-10 promotes development and progression of human glioma via the TWEAK-NF-kappaB axis (2017), Oncotarget, 8, 105262-105275 .

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Protein Variants

Protein Variants	Comment	Organism
additional information	lentiviral-mediated shRNA efficiently inhibits RDH10 expression. RDH10 knockdown impairs glioma cell proliferation in vitro	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
all-trans-retinal + NADPH + H+	Homo sapiens	-	all-trans-retinol + NADP+	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8IZV5	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
glioma cell	high RDH10 expression level, 13.89%, 43.59%, 70.59%, and 90.24% expression of RDH10 in glioma of grade I, II, III, and IV (WHO grading), respectively	Homo sapiens	-
U-87MG cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
all-trans-retinal + NADPH + H+	-	Homo sapiens	all-trans-retinol + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
RDH10	-	Homo sapiens
retinol dehydrogenase-10	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	-	Homo sapiens
NADPH	-	Homo sapiens

General Information

General Information	Comment	Organism
evolution	retinol dehydrogenase-10 (RDH10) is a member of the short-chain dehydrogenase/reductase family	Homo sapiens
malfunction	shRNA-mediated RDH10 knockdown induces glioma cell cycle arrest, impairs glioma cell proliferation in vitro, and promotes glioma apoptosis. RDH10 knockdown significantly represses several key cancer pathways including TWEAK, TNFR1 and P53. RDH10 knockdown inhibits glioma cell growth by down-regulating the TWEAK-NF-kappaB axis	Homo sapiens
physiological function	retinol dehydrogenase-10 (RDH10) plays an important role in retinoic acid (RA) synthesis, and it promotes development and progression of human glioma via the TWEAK-NF-kappaB axis. RDH10 is highly expressed in human gliomas, and its expression correlates with tumor grade and patient survival times, RDH10 expression is associated with development and progression of human glioma. RDH10 is overexpressed in human gliomas and predicts a high grade and poor prognosis. RDH10 regulates the cell cycle progression, as its loss causes an S and G2/M phase arrest, RDH10 regulates expression of glioma genes, it affects expression of genes involved in cancer, apoptosis, growth and proliferation, motility, and cell cycle	Homo sapiens

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Release 2023.1 (January 2023)