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Literature summary for 1.1.1.307 extracted from

  • Runquist, D.; Hahn-Haegerdal, B.; Bettiga, M.
    Increased ethanol productivity in xylose-utilizing Saccharomyces cerevisiae via a randomly mutagenized xylose reductase (2010), Appl. Environ. Microbiol., 76, 7796-7802.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene XYL1 Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
N272D site-directed mutagenesis, results in strain TMB 3422, the mutation enables the yeast for anaerobic growth on xylose displayed higher aerobic growth rates Saccharomyces cerevisiae
N272D/P275Q site-directed mutagenesis, results in strain TMB 3421, the mutations enable the yeast for anaerobic growth on xylose displayed higher aerobic growth rates Saccharomyces cerevisiae
P275Q site-directed mutagenesis, results in strain TMB 3423, the mutation enables the yeast for anaerobic growth on xylose displayed higher aerobic growth rates Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
xylitol + NAD+ Saccharomyces cerevisiae
-
D-xylose + NADH + H+
-
r
xylitol + NAD+ Saccharomyces cerevisiae TMB 3420
-
D-xylose + NADH + H+
-
r
xylitol + NADP+ Saccharomyces cerevisiae
-
D-xylose + NADPH + H+
-
r
xylitol + NADP+ Saccharomyces cerevisiae TMB 3420
-
D-xylose + NADPH + H+
-
r

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-
Saccharomyces cerevisiae TMB 3420
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
xylitol + NAD+
-
Saccharomyces cerevisiae D-xylose + NADH + H+
-
r
xylitol + NAD+
-
Saccharomyces cerevisiae TMB 3420 D-xylose + NADH + H+
-
r
xylitol + NADP+
-
Saccharomyces cerevisiae D-xylose + NADPH + H+
-
r
xylitol + NADP+
-
Saccharomyces cerevisiae TMB 3420 D-xylose + NADPH + H+
-
r

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Saccharomyces cerevisiae
NADH
-
Saccharomyces cerevisiae
NADP+
-
Saccharomyces cerevisiae
NADPH
-
Saccharomyces cerevisiae