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Literature summary for 1.1.1.32 extracted from

  • Ngan, H.L.; Popjak, G.
    Stereochemistry of the reaction catalyzed by mevaldate reductase (1975), Bioorg. Chem., 4, 166-180.
No PubMed abstract available

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(R)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH Sus scrofa
-
(R)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
-
?
(S)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH Sus scrofa
-
(S)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Reaction

Reaction Comment Organism Reaction ID
(R)-mevalonate + NAD+ = mevaldate + NADH + H+ stereospecific insertion of hydride into C-5, hydride is added from the re-face of carbonyl group in 3R and 3S-isomers Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.2
-
partially purified liver enzyme Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH
-
Sus scrofa (R)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
-
?
(R)-3-hydroxy-3-methyl-5-oxovaleric acid + NADPH
-
Sus scrofa (R)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NADP+
-
?
(S)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH
-
Sus scrofa (S)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
-
?

Cofactor

Cofactor Comment Organism Structure
NADH
-
Sus scrofa