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BRENDA support

Literature summary for 1.1.1.32 extracted from

  • Coon, M.J.; Kupiecki, F.P.; Dekker, E.E.; Schlesinger, M.J.; del Campillo, E.
    The enzymic synthesis of branched-chain acids (1954), CIBA Symposium on the biosynthesis of terpenes and sterols (Wolstenholme, G. E. W. ; O. Conner, M. , eds), , 62-72.
No PubMed abstract available

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(R)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH Sus scrofa
-
(R)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
-
ir
(S)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH Sus scrofa
-
(S)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
-
ir

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Reaction

Reaction Comment Organism Reaction ID
(R)-mevalonate + NAD+ = mevaldate + NADH + H+ formation of mevalonic acid is strongly favoured Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Sus scrofa
-
kidney
-
Sus scrofa
-
liver
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH
-
Sus scrofa (R)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
-
ir
(R)-3-hydroxy-3-methyl-5-oxovaleric acid + NADPH
-
Sus scrofa (R)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NADP+
-
ir
(S)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH
-
Sus scrofa (S)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
-
ir

Cofactor

Cofactor Comment Organism Structure
NADH
-
Sus scrofa