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Literature summary for 1.1.1.34 extracted from
- Hydroxymethylglutaryl CoA reductase (NADPH) in the latex of Hevea brasiliensis (1982), Phytochemistry, 21, 2613-2618.
No PubMed abstract available
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| dithiothreitol | 2 mM | Hevea brasiliensis |  |
| thiol | - |
Hevea brasiliensis | |
General Stability
| General Stability | Organism |
|---|---|
| presence of reduced thiol compounds is important for enzyme stability | Rattus norvegicus |
| presence of reduced thiol compounds is important for enzyme stability | Pisum sativum |
| presence of reduced thiol compounds is important for enzyme stability | Hevea brasiliensis |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| CoASH | - |
Pisum sativum | |
| CoASH | - |
Rattus norvegicus | |
| Hydroxymethylglutarate | 2 mM, slightly inhibitory | Hevea brasiliensis | |
| Hydroxymethylglutarate | - |
Pisum sativum | |
| MgATP2- | 4 mM | Hevea brasiliensis | |
| MgATP2- | - |
Rattus norvegicus | |
| p-chloromercuribenzoate | 1 mM, complete inhibition | Hevea brasiliensis | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.056 | - |
(R,S)-3-hydroxy-3-methylglutaryl-CoA | - |
Hevea brasiliensis | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Rattus norvegicus | 5783 | - |
| endoplasmic reticulum | - |
Pisum sativum | 5783 | - |
| membrane | lutoid | Hevea brasiliensis | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-hydroxy-3-methylglutaryl-CoA + NADPH | Rattus norvegicus | - |
(R)-mevalonate + CoA + NADP+ | - |
? | |
| 3-hydroxy-3-methylglutaryl-CoA + NADPH | Pisum sativum | - |
(R)-mevalonate + CoA + NADP+ | - |
? | |
| 3-hydroxy-3-methylglutaryl-CoA + NADPH | Hevea brasiliensis | - |
(R)-mevalonate + CoA + NADP+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Hevea brasiliensis | - |
- |
- |
| Pisum sativum | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| latex | - |
Hevea brasiliensis | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-hydroxy-3-methylglutaryl-CoA + NADPH | - |
Rattus norvegicus | (R)-mevalonate + CoA + NADP+ | - |
? | |
| 3-hydroxy-3-methylglutaryl-CoA + NADPH | - |
Pisum sativum | (R)-mevalonate + CoA + NADP+ | - |
? | |
| 3-hydroxy-3-methylglutaryl-CoA + NADPH | - |
Hevea brasiliensis | (R)-mevalonate + CoA + NADP+ | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Hevea brasiliensis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 7.5 | - |
Rattus norvegicus |
| 6.6 | 6.9 | - |
Hevea brasiliensis |
| 6.8 | - |
- |
Pisum sativum |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | - |
Hevea brasiliensis | |
| NADPH | - |
Rattus norvegicus | |
| NADPH | - |
Pisum sativum | |
| NADPH | - |
Hevea brasiliensis | |
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