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Literature summary for 1.1.1.34 extracted from

  • Chen, G.Z.; Foster, L.; Bennet, J.L.
    Purification and characterization of 3-hydroxymethylglutaryl-coenzyme A reductase of Schistosoma mansoni: Regulation of parasite enzyme activity differs from mammalien host (1991), Exp. Parasitol., 73, 82-92.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
lovastatin
-
Schistosoma mansoni

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.003
-
3-hydroxy-3-methylglutaryl-CoA
-
Schistosoma mansoni
0.052
-
NADPH
-
Schistosoma mansoni

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
66000
-
gel filtration Schistosoma mansoni

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-hydroxy-3-methylglutaryl-CoA + NADPH Schistosoma mansoni
-
(R)-mevalonate + CoA + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Schistosoma mansoni
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Schistosoma mansoni

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0036
-
-
Schistosoma mansoni

Storage Stability

Storage Stability Organism
-20°C, crude enzyme, 30 days, no loss in activity Schistosoma mansoni
-20°C, partially purified enzyme, 24-48 h, loss of most of activity Schistosoma mansoni

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-hydroxy-3-methylglutaryl-CoA + NADPH
-
Schistosoma mansoni (R)-mevalonate + CoA + NADP+
-
?

Subunits

Subunits Comment Organism
monomer 1 * 66000, SDS-PAGE Schistosoma mansoni

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Schistosoma mansoni