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Literature summary for 1.1.1.35 extracted from

  • Yang, S.Y.; He, X.Y.; Schulz, H.
    3-Hydroxyacyl-CoA dehydrogenase and short chain 3-hydroxyacyl-CoA dehydrogenase in human health and disease (2005), FEBS J., 272, 4874-4883.
    View publication on PubMed

Application

Application Comment Organism
pharmacology the short-chain 3-hydroxyacyl-CoA dehydrogenase is a target for intervention in case of Alzheimer's disease and Parkinson's disease Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Sus scrofa 5739
-
mitochondrion
-
Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is essentially involved in mitochondrial fatty acid beta-oxidation by catalyzing straight chain 3-hydroxyacyl-CoAs, the enzyme plays a role in Alzheimer's disease and Parkinson's disease, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16836
-
-
Sus scrofa
-
-
-

Reaction

Reaction Comment Organism Reaction ID
(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+ molecular reaction mechanism, a His-Glu pair is essential for actalysis in the active site Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-hydroxy-2-methylacyl-CoA + NAD+ preferred substrate of SCHAD, no activity towards 3-hydroxy-2-methylacyl-CoA by HAD Sus scrofa 3-oxo-2-methylacyl-CoA + NADH
-
?
additional information the enzyme is essentially involved in mitochondrial fatty acid beta-oxidation by catalyzing straight chain 3-hydroxyacyl-CoAs, the enzyme plays a role in Alzheimer's disease and Parkinson's disease, overview Homo sapiens ?
-
?
additional information short-chain L-3-hydroxyacyl-CoA dehydrogenase shows a wide substrate spectrum including cholic acids, steroids, and fatty acids with a preference for short-chain methyl-branched acyl-CoAs, SCHAD might be identical with 17beta-hydroxysteroid dehyxrogenase in human mitochondria, overview Homo sapiens ?
-
?
tiglyl-CoA + NAD+ activity of SCHAD Sus scrofa 3-oxo-2-methylacyl-CoA + NADH
-
?

Subunits

Subunits Comment Organism
More primary structure analysis, structure-function relationship of SCHAD, overview Sus scrofa
More structure-function relationship of SCHAD, overview Homo sapiens

Synonyms

Synonyms Comment Organism
3-hydroxyacyl-CoA dehydrogenase
-
Sus scrofa
3-hydroxyacyl-CoA dehydrogenase
-
Homo sapiens
SCHAD
-
Sus scrofa
SCHAD
-
Homo sapiens
short-chain 3-hydroxyacyl-CoA dehydrogenase
-
Sus scrofa
short-chain 3-hydroxyacyl-CoA dehydrogenase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+ dependent on Sus scrofa
NAD+ dependent on Homo sapiens