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Literature summary for 1.1.1.357 extracted from

  • Stayrook, K.R.; Rogers, P.M.; Savkur, R.S.; Wang, Y.; Su, C.; Varga, G.; Bu, X.; Wei, T.; Nagpal, S.; Liu, X.S.; Burris, T.P.
    Regulation of human 3 alpha-hydroxysteroid dehydrogenase (AKR1C4) expression by the liver X receptor alpha (2008), Mol. Pharmacol., 73, 607-612.
    View publication on PubMed
Search for more literature for 1.1.1.357

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Huh-7 and Hep-G2 cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NAD(P)+ Homo sapiens
-
 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestane + NAD(P)H + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NAD(P)+
-
 Homo sapiens 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestane + NAD(P)H + H+
-
 ?

Synonyms

Synonyms Comment Organism
3alpha-hydroxysteroid dehydrogenase
-
 Homo sapiens
AKR1C4 isoform Homo sapiens
type I 3alpha-HSD
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens
NADP+
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens liver X receptor alpha binds specifically to the liver X receptor alpha response element and mediates transcriptional activation of the AKR1C4 gene. Liver X receptor ligand T1317 induces isoform AKR1C4 expression approximately 2.3fold up

General Information

General Information Comment Organism
metabolism 3alpha-hydroxysteroid dehydrogenase isoform AKR1C4 plays a significant role in bile acid biosynthesis, steroid hormone metabolism, and xenobiotic metabolism Homo sapiens