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Literature summary for 1.1.1.36 extracted from

  • Wakil, S.J.; Bressler, R.
    Studies on the mechanism of fatty acid synthesis (1962), J. Biol. Chem., 237, 687-693.
    View publication on PubMed
Search for more literature for 1.1.1.36

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibited by p-hydroxymercuribenzoate or N-ethylmaleimide from 0.1-10 mM Pigeon

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.74
-
 acetoacetyl-CoA
-
 Pigeon

Organism

Organism UniProt Comment Textmining
Pigeon
-
-
-

Purification (Commentary)

Purification (Comment) Organism
fractionated with ammonium sulfate Pigeon

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Pigeon
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
87.9
-
 fed pigeons livers Pigeon
170.1
-
 fasted pigeons livers Pigeon
250
-
-
 Pigeon

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetoacetyl-CoA + NADPH + H+
-
 Pigeon D-beta-hydroxybutyryl-CoA + NADP+
-
 ir
acetoacetyl-CoA + NADPH + H+
-
 Pigeon (3R)-3-hydroxybutyryl-CoA + NADP+
-
 r
additional information not: crotonyl-CoA Pigeon ?
-
 ?
additional information not: octanoyl-CoA Pigeon ?
-
 ?
additional information not: beta-hydroxybutyryl-CoA Pigeon ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
 Pigeon

pH Range

pH Minimum pH Maximum Comment Organism
6.5 8.5 70-35% of initial acetoacetyl-CoA reduced Pigeon

pH Stability

pH Stability pH Stability Maximum Comment Organism
additional information
-
 above pH 8.5 acetoacetyl-CoA not stable Pigeon

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Pigeon
NADPH
-
 Pigeon