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Literature summary for 1.1.1.36 extracted from

  • Dodds, P.F.; Guzman, M.G.F.; Chalberg, S.C.; Anderson, G.J.; Kumar, S.
    Acetoacetyl-CoA reductase activity of lactating bovine mammary fatty acid synthase (1981), J. Biol. Chem., 256, 6282-6290.
    View publication on PubMed
Search for more literature for 1.1.1.36

Activating Compound

Activating Compound Comment Organism Structure
CoA stimulating Rattus norvegicus
CoA stimulating Bos taurus
pantetheine stimulating Rattus norvegicus
pantetheine stimulating Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
2-methylcrotonyl-CoA
-
 Anser sp.
2-methylcrotonyl-CoA
-
 Bos taurus
2-methylcrotonyl-CoA
-
 Gallus gallus
2-methylcrotonyl-CoA
-
 Pigeon
2-methylcrotonyl-CoA
-
 Rattus norvegicus
2-methylcrotonyl-CoA
-
 Saccharomyces cerevisiae
acetyl-CoA
-
 Anser sp.
acetyl-CoA
-
 Bos taurus
acetyl-CoA
-
 Gallus gallus
acetyl-CoA
-
 Pigeon
acetyl-CoA
-
 Rattus norvegicus
acetyl-CoA
-
 Saccharomyces cerevisiae
butyryl-CoA
-
 Anser sp.
butyryl-CoA
-
 Bos taurus
butyryl-CoA
-
 Gallus gallus
butyryl-CoA
-
 Pigeon
butyryl-CoA
-
 Rattus norvegicus
butyryl-CoA
-
 Saccharomyces cerevisiae
iodoacetamide
-
 Anser sp.
iodoacetamide
-
 Bos taurus
iodoacetamide
-
 Gallus gallus
iodoacetamide
-
 Pigeon
iodoacetamide
-
 Rattus norvegicus
iodoacetamide
-
 Saccharomyces cerevisiae
malonyl-CoA
-
 Anser sp.
malonyl-CoA
-
 Bos taurus
malonyl-CoA
-
 Gallus gallus
malonyl-CoA
-
 Pigeon
malonyl-CoA
-
 Rattus norvegicus
malonyl-CoA
-
 Saccharomyces cerevisiae
methylmalonyl-CoA
-
 Anser sp.
methylmalonyl-CoA
-
 Bos taurus
methylmalonyl-CoA
-
 Gallus gallus
methylmalonyl-CoA
-
 Pigeon
methylmalonyl-CoA
-
 Rattus norvegicus
methylmalonyl-CoA
-
 Saccharomyces cerevisiae
N-Methylmaleimide
-
 Anser sp.
N-Methylmaleimide
-
 Bos taurus
N-Methylmaleimide
-
 Gallus gallus
N-Methylmaleimide
-
 Pigeon
N-Methylmaleimide
-
 Rattus norvegicus
N-Methylmaleimide
-
 Saccharomyces cerevisiae
N-Phenylmaleimide
-
 Anser sp.
N-Phenylmaleimide
-
 Bos taurus
N-Phenylmaleimide
-
 Gallus gallus
N-Phenylmaleimide
-
 Pigeon
N-Phenylmaleimide
-
 Rattus norvegicus
N-Phenylmaleimide
-
 Saccharomyces cerevisiae
sulfhydryl reagents
-
 Anser sp.
sulfhydryl reagents
-
 Bos taurus
sulfhydryl reagents
-
 Gallus gallus
sulfhydryl reagents
-
 Pigeon
sulfhydryl reagents
-
 Rattus norvegicus
sulfhydryl reagents
-
 Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.005
-
 acetoacetyl-CoA
-
 Rattus norvegicus
0.005
-
 acetoacetyl-CoA
-
 Bos taurus
0.04
-
 S-acetoacetyl-N-acetylcysteamine
-
 Bos taurus
0.82
-
 acetoacetyl-pantetheine
-
 Bos taurus

Organism

Organism UniProt Comment Textmining
Anser sp.
-
 low activity
-
Bos taurus
-
-
-
Gallus gallus
-
 low activity
-
Pigeon
-
 low activity
-
Rattus norvegicus
-
-
-
Saccharomyces cerevisiae
-
 low activity
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue
-
 Rattus norvegicus
-
liver
-
 Gallus gallus
-
liver
-
 Rattus norvegicus
-
liver
-
 Pigeon
-
mammary gland
-
 Rattus norvegicus
-
mammary gland
-
 Bos taurus
-
uropygial gland
-
 Anser sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetoacetyl-CoA + NADPH + H+
-
 Rattus norvegicus (3R)-3-hydroxybutyryl-CoA + NADP+
-
 ir
acetoacetyl-CoA + NADPH + H+
-
 Bos taurus (3R)-3-hydroxybutyryl-CoA + NADP+
-
 ir
acetoacetyl-CoA + NADPH + H+
-
 Pigeon (3R)-3-hydroxybutyryl-CoA + NADP+
-
 ?
acetoacetyl-pantetheine + NADPH + H+
-
 Bos taurus D-3-hydroxybutyryl-pantetheine + NADP+
-
 r
S-acetoacetyl-N-acetylcysteamine + NADPH
-
 Gallus gallus 3-hydroxybutyryl-N-acetylcysteamine + NADP+
-
 ?
S-acetoacetyl-N-acetylcysteamine + NADPH
-
 Rattus norvegicus 3-hydroxybutyryl-N-acetylcysteamine + NADP+
-
 ?
S-acetoacetyl-N-acetylcysteamine + NADPH
-
 Saccharomyces cerevisiae 3-hydroxybutyryl-N-acetylcysteamine + NADP+
-
 ?
S-acetoacetyl-N-acetylcysteamine + NADPH
-
 Bos taurus 3-hydroxybutyryl-N-acetylcysteamine + NADP+
-
 ?
S-acetoacetyl-N-acetylcysteamine + NADPH
-
 Pigeon 3-hydroxybutyryl-N-acetylcysteamine + NADP+
-
 ?
S-acetoacetyl-N-acetylcysteamine + NADPH
-
 Anser sp. 3-hydroxybutyryl-N-acetylcysteamine + NADP+
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Gallus gallus
NADP+
-
 Rattus norvegicus
NADP+
-
 Saccharomyces cerevisiae
NADP+
-
 Bos taurus
NADP+
-
 Pigeon
NADP+
-
 Anser sp.
NADPH specific for Gallus gallus
NADPH specific for Rattus norvegicus
NADPH specific for Saccharomyces cerevisiae
NADPH specific for Bos taurus
NADPH specific for Pigeon
NADPH specific for Anser sp.