Cloned (Comment) | Organism |
---|---|
isozymes KCR1 and KCR2, DNA and amino acid sequence determination, expression analysis, complementation of the yeast ybr159D mutant only isozyme KCR1, overview | Arabidopsis thaliana |
Protein Variants | Comment | Organism |
---|---|---|
additional information | loss of AtKCR1 function results in embryo lethality, which cannot be rescued by AtKCR2 expression using the AtKCR1 promoter. Disruption of the AtKCR2 gene has no obvious phenotypic effect. Suppressed KCR activity results in a reduction of cuticular wax load and affects VLCFA composition of sphingolipids, seed triacylglycerols, and root glycerolipids, phenotypes, detailed overview | Arabidopsis thaliana |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Arabidopsis thaliana | 5783 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Arabidopsis thaliana | KCR catalyzes the first reduction during elongation of very-long-chain fatty acids, VLCFA, precursors of sphingolipids, triacylglycerols, cuticular waxes, and suberin in plants | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | - |
isozymes KCR1 and KCR2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | developing, KCR1 and KCR2 | Arabidopsis thaliana | - |
flower | KCR1 and KCR2 | Arabidopsis thaliana | - |
inflorescence stem | KCR1 and KCR2 | Arabidopsis thaliana | - |
leaf | KCR1 and KCR2 | Arabidopsis thaliana | - |
root | KCR1 | Arabidopsis thaliana | - |
silique | KCR1 and KCR2 | Arabidopsis thaliana | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
fatty acid and cuticular wax composition in wild-type and mutant plants, overview | Arabidopsis thaliana |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | KCR catalyzes the first reduction during elongation of very-long-chain fatty acids, VLCFA, precursors of sphingolipids, triacylglycerols, cuticular waxes, and suberin in plants | Arabidopsis thaliana | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
beta-ketoacyl reductase | - |
Arabidopsis thaliana |
beta-ketoacyl-coenzyme A reductase | - |
Arabidopsis thaliana |
KCR | - |
Arabidopsis thaliana |
General Information | Comment | Organism |
---|---|---|
metabolism | KCR catalyzes the first reduction during elongation of very-long-chain fatty acids, VLCFA, precursors of sphingolipids, triacylglycerols, cuticular waxes, and suberin in plants, but only AtKCR1 is a functional KCR isoform involved in microsomal fatty acid elongation | Arabidopsis thaliana |
physiological function | suppressed KCR activity results in a reduction of cuticular wax load and affects VLCFA composition of sphingolipids, seed triacylglycerols, and root glycerolipids | Arabidopsis thaliana |