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Literature summary for 1.1.1.36 extracted from

  • Beaudoin, F.; Wu, X.; Li, F.; Haslam, R.P.; Markham, J.E.; Zheng, H.; Napier, J.A.; Kunst, L.
    Functional characterization of the Arabidopsis beta-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase (2009), Plant Physiol., 150, 1174-1191.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
isozymes KCR1 and KCR2, DNA and amino acid sequence determination, expression analysis, complementation of the yeast ybr159D mutant only isozyme KCR1, overview Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information loss of AtKCR1 function results in embryo lethality, which cannot be rescued by AtKCR2 expression using the AtKCR1 promoter. Disruption of the AtKCR2 gene has no obvious phenotypic effect. Suppressed KCR activity results in a reduction of cuticular wax load and affects VLCFA composition of sphingolipids, seed triacylglycerols, and root glycerolipids, phenotypes, detailed overview Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Arabidopsis thaliana 5783
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Arabidopsis thaliana KCR catalyzes the first reduction during elongation of very-long-chain fatty acids, VLCFA, precursors of sphingolipids, triacylglycerols, cuticular waxes, and suberin in plants ?
-
?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
isozymes KCR1 and KCR2
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo developing, KCR1 and KCR2 Arabidopsis thaliana
-
flower KCR1 and KCR2 Arabidopsis thaliana
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inflorescence stem KCR1 and KCR2 Arabidopsis thaliana
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leaf KCR1 and KCR2 Arabidopsis thaliana
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root KCR1 Arabidopsis thaliana
-
silique KCR1 and KCR2 Arabidopsis thaliana
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
fatty acid and cuticular wax composition in wild-type and mutant plants, overview Arabidopsis thaliana

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information KCR catalyzes the first reduction during elongation of very-long-chain fatty acids, VLCFA, precursors of sphingolipids, triacylglycerols, cuticular waxes, and suberin in plants Arabidopsis thaliana ?
-
?

Synonyms

Synonyms Comment Organism
beta-ketoacyl reductase
-
Arabidopsis thaliana
beta-ketoacyl-coenzyme A reductase
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Arabidopsis thaliana
KCR
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Arabidopsis thaliana

General Information

General Information Comment Organism
metabolism KCR catalyzes the first reduction during elongation of very-long-chain fatty acids, VLCFA, precursors of sphingolipids, triacylglycerols, cuticular waxes, and suberin in plants, but only AtKCR1 is a functional KCR isoform involved in microsomal fatty acid elongation Arabidopsis thaliana
physiological function suppressed KCR activity results in a reduction of cuticular wax load and affects VLCFA composition of sphingolipids, seed triacylglycerols, and root glycerolipids Arabidopsis thaliana