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Literature summary for 1.1.1.36 extracted from

  • Singh, A.; Das, M.; Grover, A.
    Molecular mechanism of acetoacetyl-CoA enhanced kinetics for increased bioplastic production from Cupriavidus necator 428 (2020), J. Biomol. Struct. Dyn., 38, 827-840 .
    View publication on PubMed
Search for more literature for 1.1.1.36

Protein Variants

Protein Variants Comment Organism
Q47L the mutant shows with increased enzymatic efficiency compared to the wild type enzyme Cupriavidus necator
T173S the mutant shows with increased enzymatic efficiency compared to the wild type enzyme Cupriavidus necator

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetoacetyl-CoA + NADPH + H+ Cupriavidus necator
-
 (R)-3-hydroxybutyryl-CoA + NADP+
-
 r
acetoacetyl-CoA + NADPH + H+ Cupriavidus necator DSM 428
-
 (R)-3-hydroxybutyryl-CoA + NADP+
-
 r

Organism

Organism UniProt Comment Textmining
Cupriavidus necator P14697
-
-
Cupriavidus necator DSM 428 P14697
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetoacetyl-CoA + NADPH + H+
-
 Cupriavidus necator (R)-3-hydroxybutyryl-CoA + NADP+
-
 r
acetoacetyl-CoA + NADPH + H+
-
 Cupriavidus necator DSM 428 (R)-3-hydroxybutyryl-CoA + NADP+
-
 r

Synonyms

Synonyms Comment Organism
NADPH-dependent acetoacetyl-coenzyme A reductase
-
 Cupriavidus necator
PhaB
-
 Cupriavidus necator

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Cupriavidus necator