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Literature summary for 1.1.1.37 extracted from

  • Ahmadi, F.; Engel, M.; Baradarani, M.M.
    Synthesis, biological evaluation and molecular docking studies of indeno [1,2-c] pyrazol derivatives as inhibitors of mitochondrial malate dehydrogenase 2 (MDH2) (2021), Bioorg. Chem., 110, 104779 .
    View publication on PubMed
Search for more literature for 1.1.1.37

Inhibitors

Inhibitors Comment Organism Structure
(E)-3-(4-((3R,5R,7R)-adamantan-1-yl)phenoxy)-N-(5-(piperidine-1-carbonyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl) acrylamide
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-malate + NAD+ Homo sapiens
-
 oxaloacetate + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P40926
-
-

Source Tissue

Source Tissue Comment Organism Textmining
4T1 cell
-
 Homo sapiens
-
breast cancer cell line
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NAD+
-
 Homo sapiens oxaloacetate + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
malate dehydrogenase 2
-
 Homo sapiens
MDH2
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000059
-
 pH and temperature not specified in the publication Homo sapiens (E)-3-(4-((3R,5R,7R)-adamantan-1-yl)phenoxy)-N-(5-(piperidine-1-carbonyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl) acrylamide