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Literature summary for 1.1.1.37 extracted from

  • Liao, M.L.; Zhang, S.; Zhang, G.Y.; Chu, Y.M.; Somero, G.N.; Dong, Y.W.
    Heat-resistant cytosolic malate dehydrogenases (cMDHs) of thermophilic intertidal snails (genus Echinolittorina) protein underpinnings of tolerance to body temperatures reaching 55?C (2017), J. Exp. Biol., 220, 2066-2075 .
    View publication on PubMed
Search for more literature for 1.1.1.37

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Echinolittorina radiata 5829
-
cytosol
-
 Echinolittorina malaccana 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-malate + NAD+ Echinolittorina radiata
-
 oxaloacetate + NADH + H+
-
 r
(S)-malate + NAD+ Echinolittorina malaccana
-
 oxaloacetate + NADH + H+
-
 r
oxaloacetate + NADH + H+ Echinolittorina radiata
-
 (S)-malate + NAD+
-
 r
oxaloacetate + NADH + H+ Echinolittorina malaccana
-
 (S)-malate + NAD+
-
 r

Organism

Organism UniProt Comment Textmining
Echinolittorina malaccana A0A2K9YND1
-
-
Echinolittorina radiata A0A2K9YNC3
-
-

Purification (Commentary)

Purification (Comment) Organism
ammonium sulfate precipitation Echinolittorina radiata
ammonium sulfate precipitation Echinolittorina malaccana

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NAD+
-
 Echinolittorina radiata oxaloacetate + NADH + H+
-
 r
(S)-malate + NAD+
-
 Echinolittorina malaccana oxaloacetate + NADH + H+
-
 r
oxaloacetate + NADH + H+
-
 Echinolittorina radiata (S)-malate + NAD+
-
 r
oxaloacetate + NADH + H+
-
 Echinolittorina malaccana (S)-malate + NAD+
-
 r

Synonyms

Synonyms Comment Organism
cMDH
-
 Echinolittorina radiata
cMDH
-
 Echinolittorina malaccana
cytosolic malate dehydrogenase
-
 Echinolittorina radiata
cytosolic malate dehydrogenase
-
 Echinolittorina malaccana
L-malate: NAD+ oxidoreductase
-
 Echinolittorina radiata
L-malate: NAD+ oxidoreductase
-
 Echinolittorina malaccana

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
36
-
-
 Echinolittorina radiata
36
-
-
 Echinolittorina malaccana

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
25 45 more than 60% activity between 25 and 45°C Echinolittorina radiata
25 45 more than 60% activity between 25 and 45°C Echinolittorina malaccana

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
47.5 57.5 after 60 min incubation at 47.5°C, the enzyme retains 92.6% of initial activity, after 60 min incubation at 59.9°C, the enzyme still possesses 65.5% residual activity. After incubation at 57.5°C for 60 min, the enzyme is almost fully inactivated Echinolittorina radiata
47.5 57.5 after 60 min incubation at 47.5°C, the enzyme retains 95% of initial activity, after 60 min incubation at 52.5°C, the enzyme still possesses 65.5% residual activity. After incubation at 57.5°C for 60 min the enzyme retains a residual activity of 11.7% Echinolittorina malaccana

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Echinolittorina radiata
NAD+
-
 Echinolittorina malaccana
NADH
-
 Echinolittorina radiata
NADH
-
 Echinolittorina malaccana

General Information

General Information Comment Organism
metabolism the enzyme is more efficient in the reductive reaction in the tricarboxylic acid cycle Echinolittorina radiata
metabolism the enzyme is more efficient in the reductive reaction in the tricarboxylic acid cycle Echinolittorina malaccana