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Literature summary for 1.1.1.38 extracted from

  • Hou, S.; Liu, W.; Ji, D.; Zhao, Z.K.
    Efficient synthesis of triazole moiety-containing nucleotide analogs and their inhibitory effects on a malic enzyme (2011), Bioorg. Med. Chem. Lett., 21, 1667-1669.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-(5-O-phosphono-beta-D-ribofuranosyl)-4-[2-(trifluoromethyl)phenyl]-1H-1,2,3-triazole
-
Escherichia coli
4-(2-aminophenyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-1,2,3-triazole
-
Escherichia coli
4-(2-fluorophenyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-1,2,3-triazole
-
Escherichia coli
4-(2-hydroxyethyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-1,2,3-triazole
-
Escherichia coli
4-(2-methylphenyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-1,2,3-triazole
-
Escherichia coli
4-(4-fluorophenyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-1,2,3-triazole
-
Escherichia coli
4-(4-methoxyphenyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-1,2,3-triazole
-
Escherichia coli
4-(naphthalen-1-yl)-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-1,2,3-triazole
-
Escherichia coli
4-phenyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-1,2,3-triazole
-
Escherichia coli
additional information synthesis and inhibitor potencies of triazole moiety-containing nucleotide analogues, overview. The synthesis involves two key steps, the lipase-mediated selective deacylation of 1-azido-2,3,5-tri-O-acetyl-beta-D-ribofuranoside and the Huisgen 1,3-dipolar cycloaddition between terminal alkynes and the 1-azido ribofuranoside derivative Escherichia coli
N-acetyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-1,2,3-triazol-4-amine
-
Escherichia coli
N-benzoyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-1,2,3-triazol-4-amine
-
Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-malate + NAD+ Escherichia coli
-
pyruvate + CO2 + NADH
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli P26616
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NAD+
-
Escherichia coli pyruvate + CO2 + NADH
-
?

Synonyms

Synonyms Comment Organism
NAD-dependent ME
-
Escherichia coli
NAD-ME
-
Escherichia coli

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Escherichia coli

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Escherichia coli