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Literature summary for 1.1.1.39 extracted from

  • Kuo, C.W.; Hung, H.C.; Tong, L.; Chang, G.G.
    Metal-induced reversible structural interconversion of human mitochondrial NAD(P)+-dependent malic enzyme (2004), Proteins, 54, 404-411.
    View publication on PubMed
Search for more literature for 1.1.1.39

Inhibitors

Inhibitors Comment Organism Structure
Lu3+ strong inhibition, reversible slow-binding mechanism, reversible structural interconversion to the Mn2+-binding form, metal binding site structure Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ reversible structural interconversion to the Lu3+-binding form, metal binding site structure Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
m-NAD-ME
-
 Homo sapiens
mitochondrial NAD(P)+-dependent malic enzyme
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens
NADP+
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information inhibition kinetics Homo sapiens
0.0048
-
 Lu3+ isomerized enzyme form, pH 7.4, 30°C Homo sapiens
0.148
-
 Lu3+ native enzyme form, pH 7.4, 30°C Homo sapiens