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Literature summary for 1.1.1.40 extracted from

  • Jiang, P.; Du, W.; Mancuso, A.; Wellen, K.E.; Yang, X.
    Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence (2013), Nature, 493, 689-693.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.40

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-malate + NADP+ Homo sapiens
-
 pyruvate + CO2 + NADPH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NADP+
-
 Homo sapiens pyruvate + CO2 + NADPH + H+
-
 ?

Synonyms

Synonyms Comment Organism
ME2 isoform Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens p53 represses the expression of malic enzyme 1 and malic enzyme 2 down

General Information

General Information Comment Organism
malfunction down-regulation of isoform ME2 reciprocally activates p53 through distinct Mdm2 and AMP-activated kinase -mediated mechanisms in a feed-forward manner, bolstering this pathway and enhancing p53 activation. Down-regulation of isoform ME2 also modulates the outcome of p53 activation leading to strong induction of senescence, but not apoptosis Homo sapiens