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Literature summary for 1.1.1.408 extracted from

  • Zhang, X.; Carter, M.; Vetting, M.; Francisco, B.; Zhao, S.; Al-Obaidi, N.; Solbiati, J.; Thiaville, J.; Crecy-Lagard, V.; Jacobson, M.; Almo, S.; Gerlt, J.
    Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars (2016), Proc. Natl. Acad. Sci. USA, 113, E4161-E4169.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.408

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.054
-
 4-phospho-D-threonate pH 8.0, 25°C Salmonella enterica subsp. enterica serovar Typhimurium
0.12
-
 4-phospho-D-threonate pH 8.0, 25°C Cupriavidus necator
0.19
-
 4-hydroxy-L-threonine 4-phosphate pH 8.0, 25°C Salmonella enterica subsp. enterica serovar Typhimurium
0.2
-
 4-hydroxy-L-threonine 4-phosphate pH 8.0, 25°C Cupriavidus necator

Organism

Organism UniProt Comment Textmining
Cupriavidus necator Q0K4F5
-
-
Cupriavidus necator DSM 428 Q0K4F5
-
-
Salmonella enterica subsp. enterica serovar Typhimurium P58718
-
-
Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 P58718
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-dehydro-4-phospho-D-erythronate
-
 Cupriavidus necator glycerone phosphate + CO2 spontaneous reaction ?
3-dehydro-4-phospho-D-erythronate
-
 Salmonella enterica subsp. enterica serovar Typhimurium glycerone phosphate + CO2 spontaneous reaction ?
3-dehydro-4-phospho-D-erythronate
-
 Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 glycerone phosphate + CO2 spontaneous reaction ?
3-dehydro-4-phospho-D-erythronate
-
 Cupriavidus necator DSM 428 glycerone phosphate + CO2 spontaneous reaction ?
4-hydroxy-L-threonine 4-phosphate + NAD+
-
 Cupriavidus necator 3-amino-2-oxopropyl phosphate + CO2 + NADH + H+ overall reaction ?
4-hydroxy-L-threonine 4-phosphate + NAD+
-
 Salmonella enterica subsp. enterica serovar Typhimurium 3-amino-2-oxopropyl phosphate + CO2 + NADH + H+ overall reaction ?
4-hydroxy-L-threonine 4-phosphate + NAD+
-
 Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 3-amino-2-oxopropyl phosphate + CO2 + NADH + H+ overall reaction ?
4-hydroxy-L-threonine 4-phosphate + NAD+
-
 Cupriavidus necator DSM 428 3-amino-2-oxopropyl phosphate + CO2 + NADH + H+ overall reaction ?
4-phospho-D-erythronate + NAD+
-
 Cupriavidus necator glycerone phosphate + CO2 + NADH + H+ overall reaction ?
4-phospho-D-erythronate + NAD+
-
 Salmonella enterica subsp. enterica serovar Typhimurium glycerone phosphate + CO2 + NADH + H+ overall reaction ?
4-phospho-D-erythronate + NAD+
-
 Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 glycerone phosphate + CO2 + NADH + H+ overall reaction ?
4-phospho-D-erythronate + NAD+
-
 Cupriavidus necator DSM 428 glycerone phosphate + CO2 + NADH + H+ overall reaction ?
4-phospho-D-threonate + NAD+
-
 Cupriavidus necator 3-dehydro-4-phospho-D-erythronate + NADH + H+
-
 ?
4-phospho-D-threonate + NAD+
-
 Salmonella enterica subsp. enterica serovar Typhimurium 3-dehydro-4-phospho-D-erythronate + NADH + H+
-
 ?
4-phospho-D-threonate + NAD+
-
 Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 3-dehydro-4-phospho-D-erythronate + NADH + H+
-
 ?
4-phospho-D-threonate + NAD+
-
 Cupriavidus necator DSM 428 3-dehydro-4-phospho-D-erythronate + NADH + H+
-
 ?
4-phospho-D-threonate + NAD+
-
 Cupriavidus necator glycerone phosphate + CO2 + NADH + H+ overall reaction ?
4-phospho-D-threonate + NAD+
-
 Salmonella enterica subsp. enterica serovar Typhimurium glycerone phosphate + CO2 + NADH + H+ overall reaction ?
4-phospho-D-threonate + NAD+
-
 Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 glycerone phosphate + CO2 + NADH + H+ overall reaction ?
4-phospho-D-threonate + NAD+
-
 Cupriavidus necator DSM 428 glycerone phosphate + CO2 + NADH + H+ overall reaction ?

Synonyms

Synonyms Comment Organism
D-threonate 4-phosphate dehydrogenase
-
 Cupriavidus necator
D-threonate 4-phosphate dehydrogenase
-
 Salmonella enterica subsp. enterica serovar Typhimurium
DUF1537
-
 Cupriavidus necator
DUF1537
-
 Salmonella enterica subsp. enterica serovar Typhimurium
pdxA2
-
 Cupriavidus necator
pdxA2
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.35
-
 4-hydroxy-L-threonine 4-phosphate pH 8.0, 25°C Cupriavidus necator
0.37
-
 4-hydroxy-L-threonine 4-phosphate pH 8.0, 25°C Salmonella enterica subsp. enterica serovar Typhimurium
3.4
-
 4-phospho-D-threonate pH 8.0, 25°C Cupriavidus necator
8.9
-
 4-phospho-D-threonate pH 8.0, 25°C Salmonella enterica subsp. enterica serovar Typhimurium

General Information

General Information Comment Organism
physiological function members of the DUF1537 family are ATP-dependent kinases that participate in catabolic pathways for four-carbon acid sugars. PdxA2 participates in a pathway for the conversion of D-threonate to dihydroxyacetone phosphate and CO2. A strain lacking PdxA2 activity is unable to use D-threonate as a carbon source Cupriavidus necator

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1.8
-
 4-hydroxy-L-threonine 4-phosphate pH 8.0, 25°C Cupriavidus necator
1.9
-
 4-hydroxy-L-threonine 4-phosphate pH 8.0, 25°C Salmonella enterica subsp. enterica serovar Typhimurium
29
-
 4-phospho-D-threonate pH 8.0, 25°C Cupriavidus necator
160
-
 4-phospho-D-threonate pH 8.0, 25°C Salmonella enterica subsp. enterica serovar Typhimurium