Cloned (Comment) | Organism |
---|---|
genotyping in diverse cancer cell lines, overview | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | mutational analysis of IDH1 codon 132 in 1185 cancer samples, overview | Homo sapiens |
R132C | naturally occuring IDH1 mutation | Homo sapiens |
R132G | naturally occuring IDH1 mutation | Homo sapiens |
R132H | naturally occuring IDH1 mutation | Homo sapiens |
R132L | naturally occuring IDH1 mutation | Homo sapiens |
R132S | naturally occuring IDH1 mutation | Homo sapiens |
R132V | naturally occuring IDH1 mutation | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
isocitrate + NAD+ | Homo sapiens | IDH1 is an enzyme that catalyzes the oxidative decarboxylation of isocitrate into alpha-ketoglutarate utilizing either NAD+ or NADP+ as cosubstrates | 2-oxoglutarate + NADH + H+ + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-cell acute lymphoblastic leukemia cell | - |
Homo sapiens | - |
breast carcinoma cell | - |
Homo sapiens | - |
colonic carcinoma cell | - |
Homo sapiens | - |
esophageal cancer cell | - |
Homo sapiens | - |
glioblastoma cell | - |
Homo sapiens | - |
glioma cell | - |
Homo sapiens | - |
hepatoma cell | - |
Homo sapiens | - |
kidney carcinoma cell | - |
Homo sapiens | - |
leukemia cell | acute | Homo sapiens | - |
lung carcinoma cell | - |
Homo sapiens | - |
meningioma cell | malignant | Homo sapiens | - |
mesothelioma cell | - |
Homo sapiens | - |
myeloma cell | multiple | Homo sapiens | - |
ovary carcinoma cell | - |
Homo sapiens | - |
prostate adenocarcinoma cell | - |
Homo sapiens | - |
prostate carcinoma cell | - |
Homo sapiens | - |
skin carcinoma cell | - |
Homo sapiens | - |
stomach carcinoma cell | - |
Homo sapiens | - |
urinary bladder carcinoma cell | - |
Homo sapiens | - |
uterine cervix carcinoma cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
isocitrate + NAD+ | - |
Homo sapiens | 2-oxoglutarate + NADH + H+ + CO2 | - |
? | |
isocitrate + NAD+ | IDH1 is an enzyme that catalyzes the oxidative decarboxylation of isocitrate into alpha-ketoglutarate utilizing either NAD+ or NADP+ as cosubstrates | Homo sapiens | 2-oxoglutarate + NADH + H+ + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IDH1 | - |
Homo sapiens |