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Literature summary for 1.1.1.411 extracted from

  • Zhang, X.; Carter, M.; Vetting, M.; Francisco, B.; Zhao, S.; Al-Obaidi, N.; Solbiati, J.; Thiaville, J.; Crecy-Lagard, V.; Jacobson, M.; Almo, S.; Gerlt, J.
    Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars (2016), Proc. Natl. Acad. Sci. USA, 113, E4161-E4169.
    View publication on PubMedView publication on EuropePMC
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.13
-
 L-threonate cosubstrate NAD+, pH 8.0, 25°C Pectobacterium atrosepticum
0.3
-
 L-threonate cosubstrate NADP+, pH 8.0, 25°C Cupriavidus necator
0.35
-
 L-threonate cosubstrate NAD+, pH 8.0, 25°C Cupriavidus necator
0.97
-
 L-threonate cosubstrate NADP+, pH 8.0, 25°C Pectobacterium atrosepticum

Organism

Organism UniProt Comment Textmining
Cupriavidus necator Q0KBC7
-
-
Cupriavidus necator DSM 428 Q0KBC7
-
-
Pectobacterium atrosepticum Q6CZ26
-
-
Pectobacterium atrosepticum ATCC BAA-672 Q6CZ26
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-threonate + NAD+
-
 Cupriavidus necator 2-dehydro-L-erythronate + NADH + H+
-
 ?
L-threonate + NAD+
-
 Pectobacterium atrosepticum 2-dehydro-L-erythronate + NADH + H+
-
 ?
L-threonate + NAD+
-
 Pectobacterium atrosepticum ATCC BAA-672 2-dehydro-L-erythronate + NADH + H+
-
 ?
L-threonate + NAD+
-
 Cupriavidus necator DSM 428 2-dehydro-L-erythronate + NADH + H+
-
 ?
L-threonate + NADP+
-
 Cupriavidus necator 2-dehydro-L-erythronate + NADPH + H+
-
 ?
L-threonate + NADP+
-
 Pectobacterium atrosepticum 2-dehydro-L-erythronate + NADPH + H+
-
 ?
L-threonate + NADP+
-
 Pectobacterium atrosepticum ATCC BAA-672 2-dehydro-L-erythronate + NADPH + H+
-
 ?
L-threonate + NADP+
-
 Cupriavidus necator DSM 428 2-dehydro-L-erythronate + NADPH + H+
-
 ?

Synonyms

Synonyms Comment Organism
L-threonate dehydrogenase
-
 Cupriavidus necator
L-threonate dehydrogenase
-
 Pectobacterium atrosepticum
ltnD
-
 Cupriavidus necator
ltnD
-
 Pectobacterium atrosepticum

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.2
-
 L-threonate cosubstrate NADP+, pH 8.0, 25°C Cupriavidus necator
4.7
-
 L-threonate cosubstrate NADP+, pH 8.0, 25°C Pectobacterium atrosepticum
29
-
 L-threonate cosubstrate NAD+, pH 8.0, 25°C Cupriavidus necator
54
-
 L-threonate cosubstrate NAD+, pH 8.0, 25°C Pectobacterium atrosepticum

Cofactor

Cofactor Comment Organism Structure
NAD+ NAD+ is preferred over NADP+ Cupriavidus necator
NAD+ NAD+ is preferred over NADP+ Pectobacterium atrosepticum
NADP+ NAD+ is preferred over NADP+ Cupriavidus necator
NADP+ NAD+ is preferred over NADP+ Pectobacterium atrosepticum

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
4.8
-
 L-threonate cosubstrate NADP+, pH 8.0, 25°C Pectobacterium atrosepticum
7.5
-
 L-threonate cosubstrate NADP+, pH 8.0, 25°C Cupriavidus necator
85
-
 L-threonate cosubstrate NAD+, pH 8.0, 25°C Cupriavidus necator
410
-
 L-threonate cosubstrate NAD+, pH 8.0, 25°C Pectobacterium atrosepticum