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Literature summary for 1.1.1.419 extracted from

  • Lichman, B.R.; Kamileen, M.O.; Titchiner, G.R.; Saalbach, G.; Stevenson, C.E.M.; Lawson, D.M.; O'Connor, S.E.
    Uncoupled activation and cyclization in catmint reductive terpenoid biosynthesis (2019), Nat. Chem. Biol., 15, 71-79 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.419

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 cells Nepeta racemosa

Metals/Ions

Metals/Ions Comment Organism Structure
Na+ 0.1 M NaCl used in assay conditions Nepeta racemosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(+)-cis,cis-nepetalactol + NAD+ Nepeta racemosa
-
 (+)-cis,cis-nepetalactone + NADH + H+
-
 r
(+)-cis,trans-nepetalactol + NAD+ Nepeta racemosa
-
 (+)-cis,trans-nepetalactone + NADH + H+
-
 r

Organism

Organism UniProt Comment Textmining
Nepeta racemosa A0A3Q8GL18 catmint
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA agarose column chromatography, HisTrap column chromatography and Superdex 200 gel filtration Nepeta racemosa

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
 Nepeta racemosa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(+)-cis,cis-nepetalactol + NAD+
-
 Nepeta racemosa (+)-cis,cis-nepetalactone + NADH + H+
-
 r
(+)-cis,trans-nepetalactol + NAD+
-
 Nepeta racemosa (+)-cis,trans-nepetalactone + NADH + H+
-
 r

Synonyms

Synonyms Comment Organism
nepetalactol-related short-chain dehydrogenase/reductase 1
-
 Nepeta racemosa
NEPS1
-
 Nepeta racemosa

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Nepeta racemosa