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Literature summary for 1.1.1.42 extracted from

  • Ochiai, T.; Fukunaga, N.; Sasaki, S.
    Purification and some properties of two NADP+-specific isocitrate dehydrogenases from an obligately psychrophilic marine bacterium, Vibrio sp., strain ABE-1 (1979), J. Biochem., 86, 377-384.
    View publication on PubMed
Search for more literature for 1.1.1.42

Inhibitors

Inhibitors Comment Organism Structure
glyoxylate plus oxaloacetate Vibrio sp.

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ absolute requirement for divalent cations Vibrio sp.
Mn2+ absolute requirement for divalent cations Vibrio sp.

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
85000
-
 gel filtration, isoenzyme I: dimer Vibrio sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
isocitrate + NADP+ Vibrio sp.
-
 2-oxoglutarate + NADPH + H+ + CO2
-
 ?
isocitrate + NADP+ Vibrio sp. ABE-1
-
 2-oxoglutarate + NADPH + H+ + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Vibrio sp.
-
-
-
Vibrio sp. ABE-1
-
-
-

Purification (Commentary)

Purification (Comment) Organism
strain ABE-1 Vibrio sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isocitrate + NADP+
-
 Vibrio sp. 2-oxoglutarate + NADPH + H+ + CO2
-
 ?
isocitrate + NADP+
-
 Vibrio sp. ABE-1 2-oxoglutarate + NADPH + H+ + CO2
-
 ?

Subunits

Subunits Comment Organism
dimer isoenzyme I Vibrio sp.
monomer isoenzyme II, 1 * 85000, SDS-PAGE Vibrio sp.

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
20
-
 isoenzyme II Vibrio sp.
40
-
 isoenzyme I Vibrio sp.

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
20
-
 isoenzyme II Vibrio sp.

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6 8 isoenzyme I Vibrio sp.
8 8.6 isoenzyme II Vibrio sp.

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Vibrio sp.