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Literature summary for 1.1.1.42 extracted from

  • Meixner-Monori, B.; Kubicek, C.P.; Harrer, W.; Schreferl, G.; Rohe, M.
    NADP-specific isocitrate dehydrogenase from the citric acid-accumulating fungus Aspergillus niger (1986), Biochem. J., 236, 549-557.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
2-oxoglutarate substrate inhibition Aspergillus niger
ATP
-
Aspergillus niger
citrate
-
Aspergillus niger
glyoxylate plus oxaloacetate Aspergillus niger
NADPH
-
Aspergillus niger

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Aspergillus niger 5737
-
cytoplasm
-
Phycomyces blakesleeanus 5737
-
cytoplasm
-
Blastocladiella emersonii 5737
-
mitochondrion
-
Aspergillus niger 5739
-
mitochondrion
-
Phycomyces blakesleeanus 5739
-
mitochondrion
-
Blastocladiella emersonii 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ absolute requirement for divalent cations Aspergillus niger
Mn2+ absolute requirement for divalent cations Aspergillus niger

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60000
-
PAGE Aspergillus niger

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
isocitrate + NADP+ Aspergillus niger
-
2-oxoglutarate + NADPH + H+ + CO2
-
?
isocitrate + NADP+ Phycomyces blakesleeanus
-
2-oxoglutarate + NADPH + H+ + CO2
-
?
isocitrate + NADP+ Blastocladiella emersonii
-
2-oxoglutarate + NADPH + H+ + CO2
-
?

Organism

Organism UniProt Comment Textmining
Aspergillus niger
-
-
-
Blastocladiella emersonii
-
-
-
Phycomyces blakesleeanus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Aspergillus niger

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
14.4
-
-
Aspergillus niger

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isocitrate + NADP+
-
Aspergillus niger 2-oxoglutarate + NADPH + H+ + CO2
-
?
isocitrate + NADP+
-
Phycomyces blakesleeanus 2-oxoglutarate + NADPH + H+ + CO2
-
?
isocitrate + NADP+
-
Blastocladiella emersonii 2-oxoglutarate + NADPH + H+ + CO2
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
28
-
-
Aspergillus niger

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6 8
-
Aspergillus niger

pH Range

pH Minimum pH Maximum Comment Organism
6.3 7.8
-
Aspergillus niger

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Aspergillus niger
NADP+
-
Phycomyces blakesleeanus
NADP+
-
Blastocladiella emersonii