Cloned (Comment) | Organism |
---|---|
gene idh1, expression of Myc-tagged wild-type and Myc-tagged mutant enzymes in HEK-293T cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
G123R | site-directed mutagenesis, mutation is located in the catalytic domain, the mutant shows reduced activity compared to the wild-type enzyme | Homo sapiens |
R132H | site-directed mutagenesis, the mutant shows reduced activity compared to the wild-type enzyme | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
isocitrate + NADP+ | Homo sapiens | - |
2-oxoglutarate + NADPH + H+ + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O75874 | IDH1 | - |
Homo sapiens | P48735 | IDH2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-CPAP cell | - |
Homo sapiens | - |
C-643 cell | - |
Homo sapiens | - |
FB-1 cell | - |
Homo sapiens | - |
FTC-133 cell | - |
Homo sapiens | - |
HTh-7 cell | - |
Homo sapiens | - |
HTh-74 cell | - |
Homo sapiens | - |
KAT-18 cell | - |
Homo sapiens | - |
OCUT-1 cell | - |
Homo sapiens | - |
OCUT-2 cell | - |
Homo sapiens | - |
SW-1736 cell | - |
Homo sapiens | - |
thyroid cancer cell | - |
Homo sapiens | - |
thyroid cancer cell line | K1 cell | Homo sapiens | - |
thyroid cancer cell line | K5 cell | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
isocitrate + NADP+ | - |
Homo sapiens | 2-oxoglutarate + NADPH + H+ + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IDH1 | - |
Homo sapiens |
IDH2 | - |
Homo sapiens |
isocitrate dehydrogenase 1 | - |
Homo sapiens |
isocitrate dehydrogenase 2 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
27 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens |