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Literature summary for extracted from

  • Pratter, S.M.; Eixelsberger, T.; Nidetzky, B.
    Systematic strain construction and process development Xylitol production by Saccharomyces cerevisiae expressing Candida tenuis xylose reductase in wild-type or mutant form (2015), Biores. Technol., 198, 732-738 .
    View publication on PubMed


Application Comment Organism
synthesis expression of wild-type Xyl1 or an NADH-specific mutant in Saccharomyces cerevisiae. The Xyl1 mutant decreases the biocatalyst's performance, suggesting use of the NADPH-preferring wild-type enzyme when (semi-)aerobic conditions are applied. In a bioreactor process, the best-performing strain converts 40 g/l xylose with an initial productivity of 1.16 g/l/h and a xylitol yield of 100% Yamadazyma tenuis

Protein Variants

Protein Variants Comment Organism
K274R/N276D NADH-specific mutant, Saccharomyces cerevisiae expressing mutant K274R/N276D exhibits intracellular activities of 0.94 U/mg 1.07 U/mg with NADPH and NADH, respectively Yamadazyma tenuis


Organism UniProt Comment Textmining
Yamadazyma tenuis O74237


Synonyms Comment Organism
Yamadazyma tenuis


Cofactor Comment Organism Structure
Yamadazyma tenuis
Yamadazyma tenuis