Any feedback?
Literature summary for 1.1.1.44 extracted from
- The 2'-phosphate of NADP is critical for optimum productive binding to 6-phosphogluconate dehydrogenase from Candida utilis (1993), Arch. Biochem. Biophys., 305, 551-558.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| D-6-phosphogluconate | competitive substrate inhibition at pH 7 | Cyberlindnera jadinii |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0068 | - |
6-phosphogluconate | pH 10 | Cyberlindnera jadinii | |
| 0.071 | - |
6-phosphogluconate | pH 7 | Cyberlindnera jadinii | |
| 0.085 | - |
6-phosphogluconate | pH 8 | Cyberlindnera jadinii | |
| 0.204 | - |
6-phosphogluconate | pH 9 | Cyberlindnera jadinii | |
| 0.64 | - |
6-phosphogluconate | pH 9.5 | Cyberlindnera jadinii | |
| 9 | - |
NAD+ | pH 8 | Cyberlindnera jadinii | |
| 16 | - |
NAD+ | pH 7 | Cyberlindnera jadinii | |
| 17 | - |
NAD+ | pH 9.5 | Cyberlindnera jadinii | |
| 18 | - |
NAD+ | pH 9 | Cyberlindnera jadinii | |
| 114 | - |
NAD+ | pH 10 | Cyberlindnera jadinii | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 6-phospho-D-gluconate + NADP+ | Cyberlindnera jadinii | - |
D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
| 6-phospho-D-gluconate + NADP+ | Ovis aries | - |
D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cyberlindnera jadinii | - |
- |
- |
| Ovis aries | - |
lamb | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Ovis aries | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 6-phospho-D-gluconate + NAD+ | - |
Cyberlindnera jadinii | D-ribulose 5-phosphate + CO2 + NADH | - |
? | |
| 6-phospho-D-gluconate + NADP+ | - |
Cyberlindnera jadinii | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
| 6-phospho-D-gluconate + NADP+ | - |
Ovis aries | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
| beta-3-acetylpyridine adenine dinucleotide 2'-phosphate + 6-phosphogluconate | - |
Cyberlindnera jadinii | ? | - |
? | |
| beta-nicotinamide 1-N6-ethenoadenine dinucleotide 2'-phosphate + 6-phosphogluconate | - |
Cyberlindnera jadinii | ? | - |
? | |
| beta-nicotinamide adenine dinucleotide 3'-phosphate + 6-phosphogluconate | - |
Cyberlindnera jadinii | ? | - |
? | |
| beta-nicotinamide hypoxanthine dinucleotide 2'-phosphate + 6-phosphogluconate | - |
Cyberlindnera jadinii | ? | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| 3-acetylpyridine adenine dinucleotide phosphate | APADP | Cyberlindnera jadinii | |
| NAD+ | uses NAD+ very poorly as a substrate | Cyberlindnera jadinii | |
| NADP+ | uses NAD+ very poorly as a substrate | Cyberlindnera jadinii | |
| nicotinamide 1,N6-ethenoadenine dinucleotide phosphate | epsilon-NADP+ | Cyberlindnera jadinii | |
| nicotinamide adenine dinucleotide 3'-phosphate | 3'-NADP+ | Cyberlindnera jadinii | |
| nicotinamide hypoxanthine dinucleotide phosphate | HX-NADP+ | Cyberlindnera jadinii | |
| thio-NADP+ | - |
Cyberlindnera jadinii | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
