Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.44 extracted from

  • Corpas, F.J.; Garcia-Salguero, L.; Barroso, J.B.; Aranda, F.; Lupianez, J.A.
    Kinetic properties of hexose-monophosphate dehydrogenases. II. Isolation and partial purification of 6-phosphogluconate dehydrogenase from rat liver and kidney cortex (1995), Mol. Cell. Biochem., 144, 97-104.
    View publication on PubMed
Search for more literature for 1.1.1.44

Inhibitors

Inhibitors Comment Organism Structure
NADPH competitive inhibition Homo sapiens
NADPH competitive inhibition Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.157
-
 6-phosphogluconate
-
 Rattus norvegicus
0.258
-
 NADP+
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-phospho-D-gluconate + NADP+ Cyberlindnera jadinii
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
6-phospho-D-gluconate + NADP+ Gallus sp.
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
6-phospho-D-gluconate + NADP+ Homo sapiens enzyme specific for the oxidative pentose phosphate pathway D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
6-phospho-D-gluconate + NADP+ Rattus norvegicus enzyme specific for the oxidative pentose phosphate pathway D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
6-phospho-D-gluconate + NADP+ Rattus norvegicus Wistar enzyme specific for the oxidative pentose phosphate pathway D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r

Organism

Organism UniProt Comment Textmining
Cyberlindnera jadinii
-
-
-
Gallus sp.
-
 chicken
-
Homo sapiens
-
 human
-
Rattus norvegicus
-
 rat
-
Rattus norvegicus
-
 Wistar strain
-
Rattus norvegicus Wistar
-
 Wistar strain
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
kidney cortex Rattus norvegicus
-
liver
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.1207
-
 kidney enzyme, optimum conditions, pH 8.0, 37°C Rattus norvegicus
0.4242
-
 liver enzyme, optimum conditions, pH 8.0, 37°C Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-phospho-D-gluconate + NADP+
-
 Cyberlindnera jadinii D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
6-phospho-D-gluconate + NADP+
-
 Homo sapiens D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
6-phospho-D-gluconate + NADP+
-
 Rattus norvegicus D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
6-phospho-D-gluconate + NADP+
-
 Gallus sp. D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
6-phospho-D-gluconate + NADP+ enzyme specific for the oxidative pentose phosphate pathway Homo sapiens D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
6-phospho-D-gluconate + NADP+ enzyme specific for the oxidative pentose phosphate pathway Rattus norvegicus D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
6-phospho-D-gluconate + NADP+
-
 Rattus norvegicus Wistar D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
6-phospho-D-gluconate + NADP+ enzyme specific for the oxidative pentose phosphate pathway Rattus norvegicus Wistar D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r

Subunits

Subunits Comment Organism
dimer
-
 Cyberlindnera jadinii
dimer
-
 Homo sapiens
dimer
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
55
-
-
 Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
 Cyberlindnera jadinii
8
-
-
 Homo sapiens
8
-
 liver and kidney cortex enzyme Rattus norvegicus