Literature summary for 1.1.1.44 extracted from

Sundaramoorthy, R.; Iulek, J.; Barrett, M.P.; Bidet, O.; Ruda, G.F.; Gilbert, I.H.; Hunter, W.N.
Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates (2007), FEBS J., 274, 275-286.

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Application

Application	Comment	Organism
medicine	6-phosphogluconate dehydrogenase is a potential target for new drugs against African trypanosomiasis	Trypanosoma brucei

Crystallization (Commentary)

Crystallization (Comment)	Organism
-	Trypanosoma brucei
crystal structures of recombinant Lactococcus lactis 6-phosphogluconate dehydrogenase in complex with substrate, cofactor, product and inhibitors	Lactococcus lactis

Inhibitors

Inhibitors	Comment	Organism	Structure
4-phospho-D-erythronate	mimics the transition state of dehydrogenation. The inhibitor forces the catalytic lysine 185 into the protonated state	Trypanosoma brucei
4-phospho-D-erythronohydroxamic acid	-	Lactococcus lactis
5-phospho-D-ribonate	substrate analogue	Trypanosoma brucei

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.00013	-	6-phospho-D-gluconate	-	Trypanosoma brucei

Organism

Organism	UniProt	Comment	Textmining
Lactococcus lactis	P96789	-	-
Trypanosoma brucei	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Lactococcus lactis

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6-phospho-D-gluconate + NADP+	-	Trypanosoma brucei	D-ribulose 5-phosphate + CO2 + NADPH + H+	-	?

Synonyms

Synonyms	Comment	Organism
6-phosphogluconate dehydrogenase	-	Trypanosoma brucei
LlPDH	-	Lactococcus lactis

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00013	-	4-phospho-D-erythronate	-	Trypanosoma brucei
0.00095	-	5-phospho-D-ribonate	-	Trypanosoma brucei

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Release 2023.1 (January 2023)