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Literature summary for 1.1.1.44 extracted from

  • Sandoval, J.M.; Arenas, F.A.; Garcia, J.A.; Diaz-Vasquez, W.A.; Valdivia-Gonzalez, M.; Sabotier, M.; Vasquez, C.C.
    Escherichia coli 6-phosphogluconate dehydrogenase aids in tellurite resistance by reducing the toxicant in a NADPH-dependent manner (2015), Microbiol. Res., 177, 22-27.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
menadione the enzyme shows more than 4fold increased activity at 2.5 mM menadione Escherichia coli
tellurite the enzyme shows more than 4fold increased activity at 0.005 mg/ml tellurite Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
-
Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-phospho-D-gluconate + NADP+ Escherichia coli
-
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
?
6-phospho-D-gluconate + NADP+ Escherichia coli BW25113
-
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Escherichia coli BW25113
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-phospho-D-gluconate + NADP+
-
Escherichia coli D-ribulose 5-phosphate + CO2 + NADPH + H+
-
?
6-phospho-D-gluconate + NADP+
-
Escherichia coli BW25113 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
?

Subunits

Subunits Comment Organism
? x * 50000, His6-tagged enzyme, SDS-PAGE Escherichia coli

Synonyms

Synonyms Comment Organism
6-phosphogluconate dehydrogenase
-
Escherichia coli
gnd
-
Escherichia coli

Cofactor

Cofactor Comment Organism Structure
NADP+ dependent on Escherichia coli

General Information

General Information Comment Organism
physiological function the enzyme is involved in tellurite detoxification and resistance in Escherichia coli Escherichia coli