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Literature summary for 1.1.1.44 extracted from

  • Lin, R.; Elf, S.; Shan, C.; Kang, H.B.; Ji, Q.; Zhou, L.; Hitosugi, T.; Zhang, L.; Zhang, S.; Seo, J.H.; Xie, J.; Tucker, M.; Gu, T.L.; Sudderth, J.; Jiang, L.; Mitsche, M.; DeBerardinis, R.J.; Wu, S.; Li, Y.; Mao, H.; Chen, P.R.; Wang, D.; Chen, G.Z.; Hurwitz, S.J.; Lonial, S.; Arellano, M.L.; Khoury, H.J.; Khuri, F.R.
    6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling (2015), Nat. Cell Biol., 17, 1484-1496.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.44

Inhibitors

Inhibitors Comment Organism Structure
1,8-dihydroxy-3-methoxy-6-methyl-anthraquinone
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-phospho-D-gluconate + NADP+ Homo sapiens
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
212LN cell
-
 Homo sapiens
-
H-1299 cell
-
 Homo sapiens
-
H-157 cell
-
 Homo sapiens
-
H-322 cell
-
 Homo sapiens
-
HaCaT cell
-
 Homo sapiens
-
K-562 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-phospho-D-gluconate + NADP+
-
 Homo sapiens D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 ?

Synonyms

Synonyms Comment Organism
6-phosphogluconate dehydrogenase
-
 Homo sapiens
6PGD
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+ dependent on Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme suppression decreases lipogenesis and RNA biosynthesis and elevates reactive oxygen species levels in cancer cells, attenuating cell proliferation and tumor growth Homo sapiens
metabolism enzyme-mediated production of D-ribulose 5-phosphate inhibits adenine monophosphate-activated protein kinase activation by disrupting the active tumor suppressor liver kinase B1 complex, thereby activating acetyl-CoA carboxylase 1 and lipogenesis Homo sapiens
physiological function the enzyme is important for oxidative triphosphate and lipogenesis, as well as proliferative and tumor growth potential of cancer cells Homo sapiens