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Literature summary for 1.1.1.49 extracted from
- Purification and characterization of glucose-6-phosphate dehydrogenase from Aspergillus niger and Aspergillus nidulans (1993), J. Gen. Microbiol., 139, 2793-2800.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.02 | - |
NADPH | - |
Aspergillus nidulans |  |
| 0.026 | - |
NADP+ | - |
Aspergillus niger | |
| 0.03 | - |
NADP+ | - |
Aspergillus nidulans | |
| 0.092 | - |
D-glucose 6-phosphate | - |
Aspergillus nidulans | |
| 0.153 | - |
D-glucose 6-phosphate | - |
Aspergillus niger | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 53000 | - |
? * 55000 + ? * 53000, SDS-PAGE | Aspergillus niger |
| 55000 | - |
? * 55000 + ? * 53000, SDS-PAGE | Aspergillus niger |
| 57000 | - |
? * 60000 + ? * 57000, SDS-PAGE | Aspergillus nidulans |
| 60000 | - |
? * 60000 + ? * 57000, SDS-PAGE | Aspergillus nidulans |
| 160000 | - |
gel filtration | Aspergillus niger |
| 180000 | - |
gel filtration | Aspergillus nidulans |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aspergillus nidulans | - |
- |
- |
| Aspergillus niger | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Aspergillus nidulans |
- |
Aspergillus niger |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 745 | - |
purified enzyme | Aspergillus nidulans |
| 790 | - |
purified enzyme | Aspergillus niger |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glucose 6-phosphate + H2O + NADP+ | - |
Aspergillus nidulans | D-gluconate 6-phosphate + NADPH + H+ | - |
r | |
| D-glucose 6-phosphate + NADP+ | - |
Aspergillus niger | 6-phospho-D-glucono-1,5-lactone + NADPH + H+ | - |
r | |
| additional information | no activity with glucose, glucose 1-phosphate, 2-deoxyglucose 6-phosphate, fructose, fructose 6-phosphate, fructose 1,6-diphosphate, mannose, galactose 6-phosphate, NAD+ | Aspergillus nidulans | ? | - |
? | |
| additional information | no activity with glucose, glucose 1-phosphate, 2-deoxyglucose 6-phosphate, fructose, fructose 6-phosphate, fructose 1,6-diphosphate, mannose, galactose 6-phosphate, NAD+ | Aspergillus niger | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | ? * 55000 + ? * 53000, SDS-PAGE | Aspergillus niger |
| ? | ? * 60000 + ? * 57000, SDS-PAGE | Aspergillus nidulans |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 9 | - |
Aspergillus nidulans |
| 7 | 9 | - |
Aspergillus niger |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | absolute specificity | Aspergillus nidulans | |
| NADP+ | absolute specificity | Aspergillus niger | |
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