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Literature summary for 1.1.1.49 extracted from

  • Cankaya, M.; Sisecioglu, M.; Ciftci, M.; Ozdemir, H.
    Effects of some metal ions on trout liver glucose 6-phosphate dehydrogenase (2011), Res. J. Environ. Toxicol., 5, 385-391.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
Cd2+ noncompetitive inhibition Oncorhynchus mykiss
Cu2+ noncompetitive inhibition Oncorhynchus mykiss
Fe2+ strong competitive inhibition Oncorhynchus mykiss
Hg2+ noncompetitive inhibition Oncorhynchus mykiss
Pb2+ noncompetitive inhibition Oncorhynchus mykiss
Zn2+ noncompetitive inhibition Oncorhynchus mykiss

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
48500
-
x * 48500, SDS-PAGE Oncorhynchus mykiss

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucose 6-phosphate + NADP+ Oncorhynchus mykiss
-
D-glucono-1,5-lactone 6-phosphate + NADPH + H+
-
?

Organism

Organism UniProt Comment Textmining
Oncorhynchus mykiss
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme 1010fold from liver by 2',5'-ADP affinity chromatography Oncorhynchus mykiss

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Oncorhynchus mykiss
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
36.25
-
purified enzyme, pH 6.0, 25°C Oncorhynchus mykiss

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose 6-phosphate + NADP+
-
Oncorhynchus mykiss D-glucono-1,5-lactone 6-phosphate + NADPH + H+
-
?

Subunits

Subunits Comment Organism
? x * 48500, SDS-PAGE Oncorhynchus mykiss

Synonyms

Synonyms Comment Organism
G6PD
-
Oncorhynchus mykiss
glucose 6-phosphate dehydrogenase
-
Oncorhynchus mykiss

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Oncorhynchus mykiss

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
assay at Oncorhynchus mykiss

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Oncorhynchus mykiss

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.197
-
Fe2+ pH 6.0, 25°C Oncorhynchus mykiss
0.213
-
Pb2+ pH 6.0, 25°C Oncorhynchus mykiss
0.542
-
Hg2+ pH 6.0, 25°C Oncorhynchus mykiss
1.721
-
Cu2+ pH 6.0, 25°C Oncorhynchus mykiss
2.034
-
Cd2+ pH 6.0, 25°C Oncorhynchus mykiss
2.77
-
Zn2+ pH 6.0, 25°C Oncorhynchus mykiss

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.39
-
pH 6.0, 25°C Oncorhynchus mykiss Fe2+
0.78
-
pH 6.0, 25°C Oncorhynchus mykiss Pb2+
0.87
-
pH 6.0, 25°C Oncorhynchus mykiss Hg2+
1.19
-
pH 6.0, 25°C Oncorhynchus mykiss Cu2+
1.97
-
pH 6.0, 25°C Oncorhynchus mykiss Cd2+
2.16
-
pH 6.0, 25°C Oncorhynchus mykiss Zn2+

General Information

General Information Comment Organism
metabolism rate-limiting enzyme of the pentose-phosphate pathway Oncorhynchus mykiss