KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0025 | - |
oxidized 8-acetyl-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-azabenzo[de]anthracen-10-one | isozyme AKR1C3 | Homo sapiens | |
0.026 | - |
5alpha-dihydroprogesterone | isozyme AKR1C3 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-dihydroprogesterone + 2 NAD(P)H + 2 H+ | Homo sapiens | - |
pregnan-3alpha,20beta-diol + 2 NAD(P)+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Comamonas testosteroni | - |
- |
- |
Homo sapiens | - |
type 2 isozyme AKR1C3 | - |
Rattus norvegicus | - |
- |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
developemnt of noninvasive method for visualization and quantification of the reaction, development of selective fluorogenic substrate compounds, overview | Rattus norvegicus |
additional information | - |
developemnt of noninvasive method for visualization and quantification of the reaction, development of selective fluorogenic substrate compounds, overview | Comamonas testosteroni |
additional information | - |
development of noninvasive method for visualization and quantification of the reaction, development of selective fluorogenic substrate compounds, overview | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-dihydroprogesterone + 2 NAD(P)H + 2 H+ | - |
Homo sapiens | pregnan-3alpha,20beta-diol + 2 NAD(P)+ | - |
? | |
oxidized 8-acetyl-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-azabenzo[de]anthracen-10-one + NAD(P)H | synthetic compound with fluorophore core | Homo sapiens | reduced 8-acetyl-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-azabenzo[de]anthracen-10-one + NAD(P)+ | - |
r | |
oxidized 8-acetyl-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-azabenzo[de]anthracen-10-one + NAD(P)H | synthetic compound with fluorophore core | Rattus norvegicus | reduced 8-acetyl-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-azabenzo[de]anthracen-10-one + NAD(P)+ | - |
r | |
oxidized 8-acetyl-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-azabenzo[de]anthracen-10-one + NAD(P)H | synthetic compound with fluorophore core | Comamonas testosteroni | reduced 8-acetyl-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-azabenzo[de]anthracen-10-one + NAD(P)+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
3alpha-hydroxysteroid dehydrogenase | - |
Homo sapiens |
3alpha-hydroxysteroid dehydrogenase | - |
Rattus norvegicus |
3alpha-hydroxysteroid dehydrogenase | - |
Comamonas testosteroni |
3alphaHSD | - |
Homo sapiens |
3HSD | - |
Rattus norvegicus |
3HSD | - |
Comamonas testosteroni |
AKR1C3 | - |
Homo sapiens |
More | enzyme belongs to the aldo-keto reductase AKR superfamily | Homo sapiens |
PT3HSD | - |
Comamonas testosteroni |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.004 | - |
5alpha-dihydroprogesterone | isozyme AKR1C3 | Homo sapiens | |
0.14 | - |
oxidized 8-acetyl-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-azabenzo[de]anthracen-10-one | isozyme AKR1C3 | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD(P)+ | - |
Homo sapiens | |
NAD(P)+ | - |
Rattus norvegicus | |
NAD(P)+ | - |
Comamonas testosteroni | |
NAD(P)H | - |
Homo sapiens | |
NAD(P)H | - |
Rattus norvegicus | |
NAD(P)H | - |
Comamonas testosteroni |