Cloned (Comment) | Organism |
---|---|
expression in Cos-1 cells | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
apigenin | competitive inhibition with the substrate 5alpha-dihydrotestosterone, uncompetitively inhibition with the cofactor NADPH. Significantly inhibits rat AKR1C9 at 0.1 mM; competitive inhibition with the substrate 5alpha-dihydrotestosterone, uncompetitively inhibition with the cofactor NADPH. Significantly inhibits rat AKR1C9 at 0.1 mM. Apigenin is a potent inhibitor of rat AKR1C9, thereby controlling the rate of neurosteroid biosynthesis | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.003415 | - |
5alpha-dihydrotestosterone | 37°C, pH 7.2 | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-dihydrotestosterone + NADPH + H+ | Rattus norvegicus | - |
5alpha-androstan-3alpha,17beta-diol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P23457 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-dihydrotestosterone + NADPH + H+ | - |
Rattus norvegicus | 5alpha-androstan-3alpha,17beta-diol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3alpha-hydroxysteroid dehydrogenase | - |
Rattus norvegicus |
AKR1C9 | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000891 | - |
37°C, pH 7.2 | Rattus norvegicus | apigenin |