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Literature summary for 1.1.1.51 extracted from

  • Liu, H.; Robert, A.; Luu-The, V.
    Cloning and characterization of human form 2 type 7 17beta-hydroxysteroid dehydrogenase, a primarily 3beta-keto reductase and estrogen activating and androgen inactivating enzyme (2005), J. Steroid Biochem. Mol. Biol., 94, 173-179.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis, chromosome metaphase, interphase mapping, i.e. FISH mapping, localization on chromosome 10q11.2, stable expression in HEK-293 cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dihydrotestosterone + NADPH + H+ Homo sapiens androsterone inactivation 5alpha-androstane-3beta,17beta-diol + NADP+
-
?
estrone + NADPH Homo sapiens estrogen activation estradiol + NADP+
-
?
additional information Homo sapiens the isozyme might play an imporant role in modulation of active hormone levels in estrogen-sensitive cells or tissues ?
-
?
zymosterone + NADPH Homo sapiens
-
zymosterol + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dihydrotestosterone + NADPH + H+ androsterone inactivation Homo sapiens 5alpha-androstane-3beta,17beta-diol + NADP+
-
?
estrone + NADPH estrogen activation Homo sapiens estradiol + NADP+
-
?
additional information the isozyme might play an imporant role in modulation of active hormone levels in estrogen-sensitive cells or tissues Homo sapiens ?
-
?
zymosterone + NADPH
-
Homo sapiens zymosterol + NADP+
-
?

Synonyms

Synonyms Comment Organism
17beta-HSD7_2
-
Homo sapiens
form 2 type 7 17beta-hydroxysteroid dehydrogenase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens